{"title":"Chemotherapy-Induced Bone Marrow Suppression: A Bibliometrics Analysis.","authors":"Jing Yue, Huili Shui, Gao Li, Bing Yang, Dongxin Tang","doi":"10.2147/JMDH.S507187","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study seeks to investigate the key research hotspots and evolving trends in chemotherapy-induced bone marrow suppression over the past two decades by employing bibliometric visualization analysis, thereby providing a robust theoretical and empirical foundation for advancements in both scientific understanding and clinical practice.</p><p><strong>Methods: </strong>Utilizing the Web of Science Core Database, a total of 6,110 documents were retrieved and analyzed using CiteSpace and VOSviewer software. This analysis traces and evaluates the current research status, key advancements, and development trajectories of chemotherapy-induced bone marrow suppression research from 2004 to 2023.</p><p><strong>Results: </strong>The analysis included 6,110 documents, revealing a significant upward trend in research volume. The United States (1,688 papers) and China (1,528 papers) are the leading contributors, with <i>Cancer Chemotherapy and Pharmacology</i> being the most prolific journal. Keyword burst detection identified key research focuses, including nasopharyngeal carcinoma, immunotherapy, and agents such as nivolumab and pembrolizumab. These findings indicate promising directions for further exploration, such as immunotherapy for nasopharyngeal carcinoma and innovative strategies for managing bone marrow suppression with specific drugs.</p><p><strong>Conclusion: </strong>Future research may concentrate on immune checkpoint inhibitors and nasopharyngeal carcinoma. Additionally, new treatment such as the natural compound curcumin has demonstrated protective effects during chemotherapy, effectively alleviating side effects. Nutritional support strategies significantly enhance patients' quality of life during treatment, while integrative approaches that combine traditional Chinese medicine with modern medical practices reveal the potential for synergistic effects. Together, these strategies could improve clinical outcomes and effectively address the challenges posed by chemotherapy-induced bone marrow suppression.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1895-1911"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992476/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Multidisciplinary Healthcare","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JMDH.S507187","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: This study seeks to investigate the key research hotspots and evolving trends in chemotherapy-induced bone marrow suppression over the past two decades by employing bibliometric visualization analysis, thereby providing a robust theoretical and empirical foundation for advancements in both scientific understanding and clinical practice.
Methods: Utilizing the Web of Science Core Database, a total of 6,110 documents were retrieved and analyzed using CiteSpace and VOSviewer software. This analysis traces and evaluates the current research status, key advancements, and development trajectories of chemotherapy-induced bone marrow suppression research from 2004 to 2023.
Results: The analysis included 6,110 documents, revealing a significant upward trend in research volume. The United States (1,688 papers) and China (1,528 papers) are the leading contributors, with Cancer Chemotherapy and Pharmacology being the most prolific journal. Keyword burst detection identified key research focuses, including nasopharyngeal carcinoma, immunotherapy, and agents such as nivolumab and pembrolizumab. These findings indicate promising directions for further exploration, such as immunotherapy for nasopharyngeal carcinoma and innovative strategies for managing bone marrow suppression with specific drugs.
Conclusion: Future research may concentrate on immune checkpoint inhibitors and nasopharyngeal carcinoma. Additionally, new treatment such as the natural compound curcumin has demonstrated protective effects during chemotherapy, effectively alleviating side effects. Nutritional support strategies significantly enhance patients' quality of life during treatment, while integrative approaches that combine traditional Chinese medicine with modern medical practices reveal the potential for synergistic effects. Together, these strategies could improve clinical outcomes and effectively address the challenges posed by chemotherapy-induced bone marrow suppression.
期刊介绍：
The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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