Nesrin Tas, Ozge Balci, Mehmet Senes, Sukran Bicakci, Arzu Yılmaz
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引用次数: 0
Abstract
Objectives: Clinical and subclinical evidence of kidney dysfunction has been reported with the use of some anti-epileptic drugs (AEDs) in children. This study aimed to evaluate renal tubular and glomerular functions using novel biomarkers N-acetyl-β-d-glycosaminidase (NAG), Kidney Injury Molecule-1(KIM-1) and 24-hour measured creatinine clearance (mClcr) in patients taking valproic acid (VPA) and levetiracetam (LEV).
Methods: Fifty-one epileptic patients were included in this prospective case-control study between January 2023 and January 2024 in The Ankara Training and Research Hospital. Exclusions were made for individuals on multiple AEDs, those with incomplete data, bedridden patients, concurrent conditions (hypertension, obesity), or those using steroids or other medications. Participants had been on either VPA or LEV for at least six months. Sixteen healthy age- and sex-matched children served as the control group. Blood samples and 24-hour urine NAG, KIM-1, and mClcr measurements were collected.
Results: The VPA, LEV, and control group comprised 30, 21, and 16 patients, respectively. The VPA group had higher urinary pH (6.1±0.7) and mClcr levels (173.4±48.0) than LEV (5.6±0.5, 149.7±39.1) and control (5.6±0.6, 130.6±30.6) groups. No significant difference was observed in urinary pH and mClcr levels between the LEV and control groups (p>0.05). No statistically significant differences were observed among the VPA, LEV, and control groups regarding 24-hour urinary NAG, KIM-1, NAG/creatinine, and KIM-1/creatinine levels (p>0.05). There was no significant association between mClcr levels and duration of treatment or serum drug levels on Spearman's correlation coefficient (p>0.05).
Conclusion: We found VPA-associated glomerular hyperfiltration in children with epilepsy. We did not observe tubular dysfunction in patients on VPA or LEV.
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It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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