Pentraxin 3 is a Novel Inflammatory Marker of HLA-B27-associated Uveitis.

IF 2.6 4区医学 Q2 OPHTHALMOLOGY

Ocular Immunology and Inflammation Pub Date : 2025-04-15 DOI:10.1080/09273948.2025.2491565

Ahmed M Abu El-Asrar, Nele Berghmans, Saleh A Al-Obeidan, Priscilla Gikandi, Ghislain Opdenakker, Jo Van Damme, Sofie Struyf

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引用次数: 0

Abstract

Purpose: Evidence exists that pentraxin 3 (PTX3) is involved in the pathogenesis of autoimmune diseases. The aim of this study was to analyze the levels of PTX3 in aqueous humor (AH) samples from patients with specific autoimmune uveitic entities. In addition, we correlated PTX3 levels with the levels of proinflammatory cytokines and chemokines and the clinical disease activity.

Methods: AH samples from patients with active uveitis associated with human leukocyte antigen (HLA)-B27-related inflammation (n = 12), Behçet's disease (BD) (n = 13), Vogt-Koyanagi-Harada (VKH) disease (n = 12), sarcoidosis (n = 8) and control subjects (n = 9) were measured with the use of multiplex assays.

Results: When considering all uveitis patients as one group (n = 45), PTX3 levels were significantly increased compared to controls (p = 0.002). When comparing the four individual disease groups to controls, PTX3 levels were significantly higher in only HLA-B27-associated uveitis (p < 0.001). PTX3 levels were significantly higher in patients with HLA-B27-associated uveitis than in patients with BD (p = 0.034) and VKH disease (p < 0.001). PTX3 levels had a significant correlation with clinical disease activity (r = 0.480; p = 0.001) and strong positive correlations with aqueous humor levels of interferon-γ (r = 0.749; p < 0.001), interleukin (IL)-1ß (r = 0.804; p < 0.001), IL-6 (r = 707; p < 0.001), CCL20 (r = 0.691; p < 0.001) and CXCL8 (r = 0.775; p < 0.001).

Conclusions: PTX3 is an inflammatory marker and might exert a pathogenic role in HLA-B27-associated uveitis.

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戊烷素3是hla - b27相关性葡萄膜炎的一种新的炎症标志物。

目的：有证据表明penttraxin 3 （PTX3）参与自身免疫性疾病的发病机制。本研究的目的是分析特异性自身免疫性葡萄膜实体患者房水（AH）样品中的PTX3水平。此外，我们将PTX3水平与促炎细胞因子和趋化因子水平以及临床疾病活动性联系起来。方法：采用多重检测法对伴有人白细胞抗原(HLA)- b27相关炎症（n = 12）、behet病（n = 13）、Vogt-Koyanagi-Harada病（n = 12）、结节病（n = 8）和对照（n = 9）的活动性葡萄膜炎患者的AH样本进行检测。结果：将所有葡萄膜炎患者作为一组（n = 45）， PTX3水平较对照组显著升高（p = 0.002）。当将四个单独疾病组与对照组进行比较时，PTX3水平仅在hla - b27相关的葡萄膜炎（p p = 0.034）和VKH疾病(p r = 0.480；P = 0.001)，且与房水中干扰素-γ水平呈强正相关(r = 0.749；p r = 0.804；p r = 707；p r = 0.691；P r = 0.775；结论：PTX3是一种炎症标志物，可能在hla - b27相关性葡萄膜炎中起致病作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ocular Immunology and Inflammation 医学-眼科学

CiteScore

6.20

自引率

15.20%

发文量

285

审稿时长

6-12 weeks

期刊介绍： Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.