{"title":"Mechanisms and Intervention Strategies of Trimethylamine N-Oxide in Abdominal Aortic Aneurysm.","authors":"Dilixiati Abudureheman, Shuake Janaerbieke, Yuhang Song, Shuo Han, Wufuer Yimaer, Huguo Wang","doi":"10.1159/000546190","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Abdominal aortic aneurysm (AAA) is a serious cardiovascular disease with high morbidity and mortality. The role of gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) in AAA pathogenesis has attracted increasing attention.</p><p><strong>Summary: </strong>This review systematically summarizes the mechanisms by which TMAO promotes AAA development, including inflammatory activation, apoptosis induction, and extracellular matrix degradation. TMAO interacts with risk factors such as atherosclerosis and hypertension through pathways involving NF-κB, NLRP3 inflammasome, and endoplasmic reticulum stress. Intervention strategies targeting dietary precursors, gut microbiota, and key enzymes are critically evaluated.</p><p><strong>Key messages: </strong>TMAO serves as both a biomarker and a therapeutic target for AAA. Future research should prioritize personalized dietary interventions and novel TMAO inhibitors to bridge translational gaps.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-20"},"PeriodicalIF":1.7000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180771/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546190","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Abdominal aortic aneurysm (AAA) is a serious cardiovascular disease with high morbidity and mortality. The role of gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) in AAA pathogenesis has attracted increasing attention.
Summary: This review systematically summarizes the mechanisms by which TMAO promotes AAA development, including inflammatory activation, apoptosis induction, and extracellular matrix degradation. TMAO interacts with risk factors such as atherosclerosis and hypertension through pathways involving NF-κB, NLRP3 inflammasome, and endoplasmic reticulum stress. Intervention strategies targeting dietary precursors, gut microbiota, and key enzymes are critically evaluated.
Key messages: TMAO serves as both a biomarker and a therapeutic target for AAA. Future research should prioritize personalized dietary interventions and novel TMAO inhibitors to bridge translational gaps.
期刊介绍：
''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.
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