Serum vitamin C associated with lipids levels in children and adolescents: a national cross-sectional study.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2025-04-30 DOI:10.1186/s12986-025-00931-2

Xiaoqi Su, Shanliang Zhu, Ye Chen, Xin Zhou, Jun Chen, Nishant Patel, Xuming Mo

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引用次数: 0

Abstract

Background: The relationship between serum vitamin C (sVC) and blood lipids in adolescents in the US has not been thoroughly studied. This study investigates the correlation between sVC and blood lipids among adolescents using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: Data from the NHANES 2003-2006 and 2017-2018 cycles, encompassing 4,965 participants aged 12-19 years, were analyzed. sVC served as the independent variable and blood lipids as the dependent variables. Multiple linear regression models assessed the relationship between sVC and blood lipids, with subgroup analyses based on sex, age, and race. Additionally, smooth curve fitting and saturation threshold analysis were employed to explore nonlinear relationships.

Results: Adjusted analyses revealed a positive correlation between sVC and high-density lipoprotein cholesterol (HDL-C) (β = 2.77, 95%CI 2.06-3.47), with no significant association with total cholesterol, low-density lipoprotein cholesterol (LDL-C), or triglycerides. This positive correlation persisted across subgroups divided by age, gender, and race (p < 0.05). The nonlinear relationship between sVC and HDL-C was characterized by an inverted U-shaped curve in adolescents aged 12-15 years, males, females, and non-Hispanic Whites.

Conclusions: This study confirms a positive association between sVC levels and HDL-C in adolescents, suggesting that higher vitamin C intake/status may be associated with a higher HDL-C in adolescents.

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儿童和青少年血清维生素C与血脂水平相关：一项全国性横断面研究

背景：美国青少年血清维生素C （sVC）与血脂之间的关系尚未得到深入研究。本研究利用国家健康与营养检查调查（NHANES）的数据调查青少年sVC与血脂之间的相关性。方法：分析2003-2006年和2017-2018年NHANES周期的数据，包括4965名12-19岁的参与者。以sVC为自变量，血脂为因变量。多元线性回归模型评估sVC和血脂之间的关系，并基于性别、年龄和种族进行亚组分析。此外，采用光滑曲线拟合和饱和阈值分析来探索非线性关系。结果：调整后的分析显示sVC与高密度脂蛋白胆固醇（HDL-C）呈正相关（β = 2.77, 95%CI 2.06-3.47），与总胆固醇、低密度脂蛋白胆固醇（LDL-C）或甘油三酯无显著相关性。这种正相关在按年龄、性别和种族划分的亚组中仍然存在(p结论：本研究证实了青少年sVC水平和HDL-C之间的正相关，表明较高的维生素C摄入量/状态可能与青少年较高的HDL-C有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.