Caio Brenno Abreu, Bárbara Flores Culau Merlo, Márcio Penha Morterá Rodrigues, Fernanda Galante Dourado, Tullia Cuzzi Teichner, Danielle Carvalho Quintella, Denize D'Azambuja Ramos, Juliana de Sá Freire Medrado Dias
{"title":"Toward comprehending uncommon periocular manifestations: A case of localized AL amyloidosis with a rare spontaneous eyelid ecchymosis.","authors":"Caio Brenno Abreu, Bárbara Flores Culau Merlo, Márcio Penha Morterá Rodrigues, Fernanda Galante Dourado, Tullia Cuzzi Teichner, Danielle Carvalho Quintella, Denize D'Azambuja Ramos, Juliana de Sá Freire Medrado Dias","doi":"10.1177/11206721251333603","DOIUrl":null,"url":null,"abstract":"<p><p>IntroductionAmyloidosis, characterized by extracellular protein misfolding and deposition. Localized immunoglobulin light chain amyloidosis can present with atypical features.Case presentationThis case report elucidates an unconventional manifestation of localized immunoglobulin light chain amyloidosis characterized by recurrent and spontaneous eyelid ecchymosis alternating with episodes of incomplete resolution, a novelty in current literature, along with associated cutaneous changes.DiscussionThis rare presentation underscores the importance of considering amyloidosis in the differential diagnosis of unusual periocular findings and may assist in identifying similar cases of atypical eyelid amyloidosis, especially in cases with limited involvement, promoting early diagnosis and intervention.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP53-NP58"},"PeriodicalIF":1.4000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/11206721251333603","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
IntroductionAmyloidosis, characterized by extracellular protein misfolding and deposition. Localized immunoglobulin light chain amyloidosis can present with atypical features.Case presentationThis case report elucidates an unconventional manifestation of localized immunoglobulin light chain amyloidosis characterized by recurrent and spontaneous eyelid ecchymosis alternating with episodes of incomplete resolution, a novelty in current literature, along with associated cutaneous changes.DiscussionThis rare presentation underscores the importance of considering amyloidosis in the differential diagnosis of unusual periocular findings and may assist in identifying similar cases of atypical eyelid amyloidosis, especially in cases with limited involvement, promoting early diagnosis and intervention.
期刊介绍:
The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.