Antiseptic activity of different ophthalmic formulations: an in vitro study.

IF 3.3 4区医学 Q1 Medicine

European review for medical and pharmacological sciences Pub Date : 2025-04-01 DOI:10.26355/eurrev_202504_37163

C Cagini, M Spinosi, F Della Lena, M P Carafa, D Marini, C Russo, D Pietrella

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引用次数: 0

Abstract

OBJECTIVE: The aim of the study was to evaluate the in vitro antiseptic power of nine ophthalmic preparations containing active ingredients with known antimicrobial properties: Polyhexamethylene biguanide 0.0003%; Hexamidine diisethionate 0.1%; chlorhexidine digluconate 0.02%; Povidone-iodine 0.6%; Hexamidine diisethionate 0.05% and polyhexanide hydrochloride 0.0001%; Hypochlorous acid 0.011%; Biosecur 2 g/100 mL; Self-preserved ozonated vegetable oil; Polyquaternium-133 0.1%. MATERIALS AND METHODS: Organisms were selected based on the current review of endophthalmitis literature: Staphylococcus aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 35984), Pseudomonas aeruginosa (ATCC 15692) and Candida albicans (SC5314). The effect of the eye drops on bacterial cultures and yeast cells was evaluated using the Minimum Inhibitory Concentration assay and growth kinetics analysis. RESULTS: All tested ophthalmic solutions demonstrated antiseptic activity by reducing the microbial load of the selected organisms in vitro. At higher dilutions, some formulations maintained antiseptic properties. CONCLUSIONS: The antiseptic power of ophthalmic preparations tested in vitro is effective against species of microorganisms responsible for eye infections. Polyquaternium-133 0.1% has shown the best antiseptic activity, proving to inhibit or slow down the growth of microorganisms even at low concentrations.

Graphical abstract: https://www.europeanreview.org/wp/wp-content/uploads/ART.-14034-Graphical-abstract-OK-scaled.jpg.

查看原文本刊更多论文

不同眼科配方的抗菌活性：体外研究。

目的：评价含有已知抗菌活性成分的9种眼科制剂的体外抗菌能力：聚六亚甲基二胍0.0003%；二乙二酸己胺0.1%；二光酸氯己定0.02%；聚乙烯吡咯酮碘0.6%;二乙磺酸己胺0.05%，盐酸聚己胺0.0001%；次氯酸0.011%；biosecurity 2 g/100 mL；自保存臭氧化植物油；polyquaternium - 133 0.1%。材料和方法：根据目前对眼内炎文献的回顾，选择生物：金黄色葡萄球菌（ATCC 29213）、表皮葡萄球菌（ATCC 35984）、铜绿假单胞菌（ATCC 15692）和白色念珠菌（SC5314）。使用最小抑制浓度法和生长动力学分析评估滴眼液对细菌培养物和酵母细胞的影响。结果：所有测试的眼科溶液都通过降低选定生物的体外微生物负荷而显示出抗菌活性。在较高的稀释度下，一些配方保持了防腐性能。结论：眼用制剂体外抗菌能力对引起眼部感染的微生物有效。聚季铵盐-133 0.1%显示出最好的杀菌活性，即使在低浓度下也能抑制或减缓微生物的生长。图形摘要：https://www.europeanreview.org/wp/wp-content/uploads/ART.-14034-Graphical-abstract-OK-scaled.jpg。

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来源期刊

European review for medical and pharmacological sciences 医学-药学

CiteScore

5.30

自引率

6.10%

发文量

906

审稿时长

2-4 weeks

期刊介绍： European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)