Prognosis of nasopharyngeal carcinoma in children and adolescents: a population-based analysis.

IF 2 3区医学 Q2 PEDIATRICS

BMC Pediatrics Pub Date : 2025-04-21 DOI:10.1186/s12887-025-05653-1

Yi Shi, Yang Wu, Jiezhi He, Yinjie Ling, Wenyuan Liu

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引用次数: 0

Abstract

Objectives: The purpose of this study is to use a population-based cohort to examine the clinicopathological features and survival outcomes of nasopharyngeal cancer (NPC) in children and adolescents.

Methods: Demographic and clinicopathological variables of pediatric patients diagnosed with NPC were extracted from the Surveillance, Epidemiology, and End Results database (2000-2018). The survival rates were calculated using Kaplan-Meier analysis. Univariate survival analysis used the log-rank test, whereas multivariate analysis used Cox proportional-hazards regression to find factors impacting overall survival (OS).

Results: A total of 233 pediatric patients were analyzed, with a median age at diagnosis of 16 years (range: 7-19 years). The cancers primarily affected males (70.0%). In terms of grade, 8 (3.5%) patients were well and moderately differentiated, 31 (13.3%) patients were poorly differentiated, and 134 (57.5%) patients were undifferentiated. TNM stage and radiotherapy were significant independent predictors of overall survival. The risk of death was higher for M1 stage (hazard ratio (HR) 20.1, 95% confidence interval (CI), 8.0-50.5; P < 0.001) as compared to M0 stage. Furthermore, multivariate analysis revealed a significant survival advantage for radiotherapy treatment (HR 0.24, 95% CI, 0.09-0.68; P = 0.007).

Conclusion: NPC in children is rare and should be studied independently. This study found that TNM stage and radiotherapy were the most significant survival predictors, emphasizing the importance of these parameters in the prediction and treatment of pediatric NPC.

Level of evidence: 3:

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儿童和青少年鼻咽癌的预后：一项基于人群的分析。

目的：本研究的目的是使用基于人群的队列来检查儿童和青少年鼻咽癌（NPC）的临床病理特征和生存结局。方法：从监测、流行病学和最终结果数据库（2000-2018）中提取诊断为鼻咽癌的儿科患者的人口学和临床病理变量。生存率采用Kaplan-Meier分析计算。单因素生存分析使用log-rank检验，而多因素分析使用Cox比例风险回归来寻找影响总生存（OS）的因素。结果：共分析了233例儿科患者，诊断时的中位年龄为16岁（范围：7-19岁）。癌症主要影响男性（70.0%）。分级方面，8例（3.5%）患者为良好和中度分化，31例（13.3%）患者为低分化，134例（57.5%）患者为未分化。TNM分期和放疗是总生存期的重要独立预测因子。M1期的死亡风险较高(风险比（HR） 20.1, 95%可信区间（CI） 8.0 ~ 50.5；结论：小儿鼻咽癌少见，应独立研究。本研究发现TNM分期和放疗是最重要的生存预测指标，强调了这些参数在小儿鼻咽癌预测和治疗中的重要性。证据等级：3；

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.