Enhanced reciprocal connections of the prefrontoparietal-thalamo-hippocampal circuit in older adults.

IF 2.9 2区医学 Q2 NEUROSCIENCES

Cerebral cortex Pub Date : 2025-04-01 DOI:10.1093/cercor/bhaf080

Zhen Ouyang, Haixia Jiang, Feng Zhang, Xue Wang, Chuqiao Geng, Mingjuan Zhao, Dong Cui, Zihao Zheng, Li Dong, Qing Jiao, Weifang Cao

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引用次数: 0

Abstract

Cognitive functions rely on specific brain circuits involving cortical and subcortical regions. However, how age-related changes in effective connectivity within the prefrontoparietal-thalamo-hippocampal circuit affect cognition remains unclear. This study included 143 healthy older adults (60 to 88 yrs) and 124 young adults (18 to 44 yrs), using regression dynamic causal modeling to analyze resting-state functional magnetic resonance imaging data. Compared to young adults, older adults showed increased reciprocal effective connectivity within the ventromedial prefrontal cortex-lateral thalamic nuclei-right caudal hippocampus circuit. Enhanced bidirectional connectivity was also observed within the frontoparietal network, between the pregenual cingulate gyrus and superior frontal gyrus, and between lateral thalamic nuclei (LTN) and frontal pole. Additionally, heightened connectivity between thalamus and hippocampus negatively correlated with cognitive performance. Our findings reveal significant age-related increases in effective connectivity within the prefrontoparietal-thalamo-hippocampal circuit, linked to cognitive performance levels. Increased connectivity may indicate compensatory mechanisms helping preserve cognitive function in healthy aging. These results advance our understanding of neural dynamics underlying cognitive aging and potential adaptive mechanisms in older adults.

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老年人前额叶-顶叶-丘脑-海马回路的相互连接增强。

认知功能依赖于涉及皮层和皮层下区域的特定脑回路。然而，前额叶顶叶-丘脑-海马体回路中有效连接的年龄相关变化如何影响认知仍不清楚。本研究纳入143名健康老年人（60 ~ 88岁）和124名年轻人（18 ~ 44岁），采用回归动态因果模型分析静息状态功能磁共振成像数据。与年轻人相比，老年人在腹内侧前额叶皮层-外侧丘脑核-右侧尾侧海马回路中显示出增强的相互有效连通性。前额顶叶网络、前扣带回与额上回之间、外侧丘脑核（LTN）与额极之间的双向连通性也有所增强。此外，丘脑和海马体之间的连接增强与认知表现呈负相关。我们的研究结果显示，前额叶-顶叶-丘脑-海马体回路中有效连通性的显著增长与年龄有关，与认知表现水平有关。增加的连通性可能表明代偿机制有助于保持健康衰老的认知功能。这些结果促进了我们对老年人认知老化和潜在适应机制的神经动力学的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.