Association between triglyceride glucose index and depression in polycystic ovary syndrome.

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Guili Chen, Lin Zhu, Ying Lou, Yingyun Wu, Lanying Wang, Weirong Mao, Jianting Ma
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引用次数: 0

Abstract

Objective: The relationship between the triglyceride glucose (TyG) index and the incidence of depression in populations with polycystic ovary syndrome (PCOS) remains unclear. This study aims to investigate the relationship between the TyG index and depression incidence in PCOS populations.

Methods: We conducted a study on 725 women aged 18 to 45 who visited our hospital from January 2021 to December 2023. Demographic and anthropometric data were collected, and serum assays were performed. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess the past week's feelings and determine depression status. Statistical methods such as binary logistic regression analysis were used to analyze the relationship between the TyG index, Homeostatic model assessment insulin resistance index(HOMA-IR), and depression in PCOS patients. The TyG index, HOMA-IR, was tested for its ability to predict depression using receiver operating characteristic (ROC) curves.

Results: In logistic regression models, a significant positive association was observed between the TyG index and depression after the adjusted analysis(4.552(2.975 ∼ 6.966), P<0.001). Compared to HOMA-IR(1.224(1.122 ∼ 1.336), P<0.001), the TyG index was a more significant risk factor for depression. ROC analysis showed that the AUC of the TyG index(0.724, 0.684 ∼ 0.765) was higher than the HOMA-IR(0.698,0.656~0.74).

Conclusions: A high TyG index was associated with higher odds of having depression in the population with PCOS. This indicated that the TyG index may be an independent predictor of depression development.

Clinical trial number: Not applicable.

甘油三酯葡萄糖指数与多囊卵巢综合征抑郁的关系。
目的:多囊卵巢综合征(PCOS)人群甘油三酯葡萄糖(TyG)指数与抑郁发生率的关系尚不清楚。本研究旨在探讨TyG指数与PCOS人群抑郁发生率的关系。方法:对2021年1月至2023年12月来我院就诊的725名18 ~ 45岁女性进行研究。收集人口统计学和人体测量学数据,并进行血清测定。流行病学研究中心抑郁量表(CES-D)用于评估过去一周的感受并确定抑郁状态。采用二元logistic回归分析等统计方法,分析PCOS患者TyG指数、稳态模型评估胰岛素抵抗指数(HOMA-IR)与抑郁的关系。使用受试者工作特征(ROC)曲线测试TyG指数(HOMA-IR)预测抑郁症的能力。结果:在logistic回归模型中,经过调整分析,TyG指数与抑郁症之间存在显著的正相关(4.552(2.975 ~ 6.966))。结论:高TyG指数与PCOS患者患抑郁症的几率较高相关。这表明TyG指数可能是抑郁症发展的独立预测因子。临床试验号:不适用。
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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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