The association between anhedonia and prefrontal cortex activation in patients with major depression: a functional near-infrared spectroscopy study.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY

European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2025-04-23 DOI:10.1007/s00406-025-02010-2

Li-Fen Chen, Ching-En Lin, Chi-Hsiang Chung, Yong-An Chung, Sonya Youngju Park, Wei-Chou Chang, Chuan-Chia Chang, Hsin-An Chang

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Abstract

This study investigated cerebral blood flow characteristics using functional nearinfrared spectroscopy (fNIRS) in agomelatine-treated depressed patients with anhedonia. The level of anhedonia was assessed by the Snaith Hamilton Rating Scale (SHAPS) and Montgomery Åsberg Depression Rating Scale 5-item (MADRS 5-item) score. All 84 patients were evaluated on the day of the study initiation and followed at week 1, 4 and 8 after the study initiation. Graph theory-based network analysis showed 2-back task-modulated global efficiency (adjusted B = 0.055, 95% CI = 0.043 - 0.066) and local efficiency (adjusted B = 0.066, 95% CI = 0.050 - 0.081) were significantly increased 1 week after treatment compared with the baseline. Furthermore, the increased oxy-hemoglobin (oxy-Hb) values from the baseline to the one week after treatment was positively related to the total MADRAS 5-item score reductions in the left-hemispheric orbitofrontal cortex (r = - 0.307, p = 0.005). Our findings suggest that abnormal functional connectivity over OFC may reflect the pathophysiological characteristics of anhedonia and serve as a clinical biomarker for anhedonia.

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重度抑郁症患者快感缺乏与前额皮质激活之间的关系：一项功能性近红外光谱研究。

本研究利用功能性近红外光谱（fNIRS）研究阿戈美拉汀治疗抑郁症伴快感缺乏患者的脑血流特征。采用Snaith Hamilton评定量表（SHAPS）和Montgomery抑郁评定量表Åsberg 5项评分（MADRS 5项）评定快感缺乏水平。所有84例患者在研究开始当天进行评估，并在研究开始后的第1、4和8周进行随访。基于图论的网络分析显示，治疗后1周，2-back任务调节的整体效率（调整后B = 0.055, 95% CI = 0.043 - 0.066）和局部效率（调整后B = 0.066, 95% CI = 0.050 - 0.081）较基线显著提高。此外，从基线到治疗后一周，氧合血红蛋白（oxy-Hb）值的增加与左半球眶额皮质MADRAS 5项总分的降低呈正相关（r = - 0.307, p = 0.005）。我们的研究结果表明，OFC上异常的功能连接可能反映了快感缺乏的病理生理特征，并可作为快感缺乏的临床生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Psychiatry and Clinical Neuroscience 医学-精神病学

CiteScore

8.80

自引率

4.30%

发文量

154

审稿时长

6-12 weeks

期刊介绍： The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.