Drug-related falls: proportion and impact of hospitalizations in geriatric departments on the prescription of fall-risk increasing drugs (FRIDs).

Abstract

Purpose: The incidence of drug-related admissions in France was 8.5% in 2018, with falls being the 5 th cause of DRA. The screening of adverse drug reactions (ADRs) in old adults can be challenging. Our objective was to determine the proportion of old patients hospitalized for drug-related falls in a geriatrics department, assess their preventability and the impact of hospitalizations on the prescription of fall-risk increasing drugs (FRIDs).

Methods: A retrospective observational study, including patients aged over 75 years who were admitted to an acute geriatrics medicine department from May 10, 2022, to February 2, 2023, was conducted. We used a previously published method to detect DRA and assess their preventability.

Results: Of the 512 patients admitted to the department during the study period, 104 patients (20%) were hospitalized due to falls, of whom 71 (14%) were considered to be drug-related. Falls associated with drugs were categorized as more severe (p = 0.01). In 41% of drug-related falls, ADRs were considered to be definitively avoidable. The most commonly implicated FRIDs classes were beta-blockers (53%, n = 38); diuretics (47%, n = 34); antidepressants (41%, n = 29); benzodiazepines (6%, n = 20); and underuse of vitamin D in patients with a documented deficiency (65%, n = 46). In patients hospitalized for drug-related falls, the FRIDs decreased between admission (n = 314) and discharge (n = 198, p < 0.01).

Conclusion: The proportion of hospitalizations for drug-related falls is notably high in geriatric department, and a substantial proportion can be prevented. These findings emphasize the importance of targeting high-risk patients for falls and implementing preventive measures, such as reassessing their medication as recommended in the latest international guidelines for falls prevention.