Recent Synthetic Advancement and Medicinal Applications of Asymmetric Cyclic Pyrazoline-based Hydrazine Derivatives: A Review.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-04-30 DOI:10.2174/0115680266374814250422053723

Dattatraya Raut, Raghunath Bhosale, Dnyandev Bhosale, Anjana Lawand, Mahesh Hublikar

引用次数: 0

Abstract

Chemistry research focuses on reducing energy and minimizing harmful byproducts. Pyrazoline and its derivatives have various pharmacological properties. This study aims to compile procedures for creating pyrazoline scaffolds from academic articles and online resources, such as Scopus, Google Scholar, Web of Science, Science Direct, Research Gate and libraries, aiming to minimize environmental and human health impacts. The primary objective is to determine the structural modifications and chemical groups that enhance their bioactivity, low toxicity, and handling. Furthermore, the review explores the bioavailability, synthetic challenges, and progress made in utilising pyrazoline derivatives in pharmaceutical and synthetic organic chemistry. The only goal is to provide insight into the creation of pyrazoline hybrid molecules that are very effective and less hazardous.

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不对称环吡唑啉类联氨衍生物的合成进展及医药应用综述

化学研究的重点是减少能量和尽量减少有害的副产品。吡唑啉及其衍生物具有多种药理性质。本研究旨在从学术文章和在线资源（如Scopus、谷歌Scholar、Web of Science、Science Direct、Research Gate和图书馆）中编制吡唑啉支架的构建程序，以最大限度地减少对环境和人类健康的影响。主要目的是确定结构修饰和化学基团，以提高其生物活性，低毒性和处理。此外，综述了吡唑啉衍生物的生物利用度、合成挑战以及在制药和合成有机化学中的应用进展。唯一的目标是深入了解吡唑啉杂化分子的创造，这种分子非常有效，危害更小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.