Unraveling the Nano World in Paracoccidioidomycosis: Promising Applications of Nanotechnology in Diagnosis, Treatment, and Vaccines: A Mini Review.

IF 2.3 3区生物学 Q3 MICROBIOLOGY

Current Microbiology Pub Date : 2025-04-28 DOI:10.1007/s00284-025-04251-9

Ricardo Cervini, Ariana Centa, Claudriana Locatelli, Gustavo Colombo Dal Pont, João Paulo Assolini

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引用次数: 0

Abstract

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by fungi of the genus Paracoccidioides. This disease is prevalent in Latin America, with Brazil being an endemic region. This mycosis can be classified as PCM infection, PCM disease and residual PCM. Although diagnosis and treatment exist, they have some limitations, and there is no vaccine available for this disease. Thus, the application of nanotechnology in the biomedical and health areas has become an innovative alternative. In this review, we highlight the main advances in the use of nanotechnology to improve and/or develop methods of diagnosis, treatment and vaccines for PCM. In order to improve diagnostic methods, nanoparticles can be used as biosensors associated with cell biology and spectroscopy techniques. The use of nanomaterials of different shapes and nature can act directly on the pathogen or as drug carriers, maintaining or improving antifungal activity and reducing toxicity in vitro and in vivo. In addition, nanoparticulate systems could be an important tool for vaccine development, stimulating a Th1 response, which is considered protective in PCM.

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揭示副球孢子菌病的纳米世界：纳米技术在诊断、治疗和疫苗中的应用前景：一个小型综述。

副球孢子菌病（PCM）是一种由副球孢子菌属真菌引起的系统性真菌病。这种疾病在拉丁美洲流行，巴西是一个流行地区。这种真菌病可分为PCM感染、PCM病和残留PCM。虽然有诊断和治疗，但它们有一些局限性，而且没有针对这种疾病的疫苗。因此，纳米技术在生物医学和卫生领域的应用已成为一种创新的替代方案。在这篇综述中，我们重点介绍了利用纳米技术改进和/或开发PCM的诊断、治疗方法和疫苗的主要进展。为了改进诊断方法，纳米颗粒可以用作与细胞生物学和光谱学技术相关的生物传感器。使用不同形状和性质的纳米材料可以直接作用于病原体或作为药物载体，维持或提高抗真菌活性，降低体外和体内毒性。此外，纳米颗粒系统可以成为疫苗开发的重要工具，刺激Th1反应，被认为对PCM有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Microbiology 生物-微生物学

CiteScore

4.80

自引率

3.80%

发文量

380

审稿时长

2.5 months

期刊介绍： Current Microbiology is a well-established journal that publishes articles in all aspects of microbial cells and the interactions between the microorganisms, their hosts and the environment. Current Microbiology publishes original research articles, short communications, reviews and letters to the editor, spanning the following areas: physiology, biochemistry, genetics, genomics, biotechnology, ecology, evolution, morphology, taxonomy, diagnostic methods, medical and clinical microbiology and immunology as applied to microorganisms.