{"title":"Exploring quinazoline-derived copper(I) complex coated intravaginal ring against vulvovaginal candidiasis causing <i>Candida</i> species.","authors":"Dhesiga Krishnan, Sudaarsan Aruna Senthil Kumar, Sowndarya Jothipandiyan, Venkatesan Yamuna Devi, Devarajan Suresh, Paramasivam Nithyanand","doi":"10.1080/08927014.2025.2489479","DOIUrl":null,"url":null,"abstract":"<p><p>Vulvovaginal candidiasis (VVC) is especially prevalent among intrauterine device (IUD) and intravaginal ring (IVR) users. <i>Candida albicans</i> is the leading causative agent of VVC followed by <i>Candida glabrata</i>. Ascribed to the increased drug resistance by <i>Candida</i> spp. to the currently available drugs, this study has focused on the novel quinazoline-derived copper(I) complexes as anti-candida agents. As a novel approach, a vaginal ring was coated with the best quinazoline-derived copper(I) complex, and biofilm disruption ability was evaluated. The coated vaginal ring eradicated 70% of preformed biofilms and also inhibited the hyphal transition of <i>Candida albicans</i> in a simulated vaginal fluid (SVF). The overall study validates the anti-biofilm and anti-virulent properties of the metal complex-coated vaginal ring using various microscopic studies.</p>","PeriodicalId":8898,"journal":{"name":"Biofouling","volume":"41 4","pages":"378-393"},"PeriodicalIF":2.6000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biofouling","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1080/08927014.2025.2489479","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/23 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Vulvovaginal candidiasis (VVC) is especially prevalent among intrauterine device (IUD) and intravaginal ring (IVR) users. Candida albicans is the leading causative agent of VVC followed by Candida glabrata. Ascribed to the increased drug resistance by Candida spp. to the currently available drugs, this study has focused on the novel quinazoline-derived copper(I) complexes as anti-candida agents. As a novel approach, a vaginal ring was coated with the best quinazoline-derived copper(I) complex, and biofilm disruption ability was evaluated. The coated vaginal ring eradicated 70% of preformed biofilms and also inhibited the hyphal transition of Candida albicans in a simulated vaginal fluid (SVF). The overall study validates the anti-biofilm and anti-virulent properties of the metal complex-coated vaginal ring using various microscopic studies.
期刊介绍：
Biofouling is an international, peer-reviewed, multi-discliplinary journal which publishes original articles and mini-reviews and provides a forum for publication of pure and applied work on protein, microbial, fungal, plant and animal fouling and its control, as well as studies of all kinds on biofilms and bioadhesion.
Papers may be based on studies relating to characterisation, attachment, growth and control on any natural (living) or man-made surface in the freshwater, marine or aerial environments, including fouling, biofilms and bioadhesion in the medical, dental, and industrial context.
Specific areas of interest include antifouling technologies and coatings including transmission of invasive species, antimicrobial agents, biological interfaces, biomaterials, microbiologically influenced corrosion, membrane biofouling, food industry biofilms, biofilm based diseases and indwelling biomedical devices as substrata for fouling and biofilm growth, including papers based on clinically-relevant work using models that mimic the realistic environment in which they are intended to be used.
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