Assessment of the relationship between serum magnesium levels, patent ductus arteriosus, and other neonatal morbidities: a retrospective observational study.

IF 0.9 4区 医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Selma Aktas, Eda Albayrak, Osman Guvenc, Ebru Kazanci, Aysegul Inamlik, Ayse Pelin Ozcan, Ayse Korkmaz, Serdar Beken
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Abstract

Objective: This study aimed to evaluate the association between serum magnesium levels and the risk of symptomatic patent ductus arteriosus in premature infants.

Material and method: This retrospective single-centre cohort study analysed the medical records of patients. Neonates were categorised into two groups based on the presence or absence of symptomatic patent ductus arteriosus. Demographic factors including gender, gestational age, type of birth, birth weight, multiple pregnancies, medical treatment for duct closure or surgical ligation, length of hospital stay, and mortality and neonatal outcomes were compared between the groups. The relationship between serum magnesium levels at 24 hours of age and the risk of symptomatic patent ductus arteriosus and other neonatal morbidities was assessed.

Results: This study found no significant relationship between symptomatic patent ductus arteriosus and serum magnesium levels. Additionally, no significant differences were observed between serum magnesium levels and ductal diameter, nor in the need for medical or surgical intervention for symptomatic patent ductus arteriosus. However, neonates with serum magnesium levels greater than 3 mg/dL exhibited a significantly higher incidence of respiratory distress syndrome. Conversely, the prevalence of bronchopulmonary dysplasia was significantly lower in this group, with both findings reaching statistical significance (p < 0.05).

Conclusion: These results suggest that while serum magnesium levels may not be a reliable marker for symptomatic patent ductus arteriosus, they could have clinical implications in the modulation of neonatal respiratory outcomes. Further research is warranted to explore the underlying mechanisms and assess the potential therapeutic role of magnesium in the management of neonatal morbidities.

评估血清镁水平、动脉导管未闭和其他新生儿发病率之间的关系:一项回顾性观察性研究。
目的:本研究旨在评价血清镁水平与早产儿症状性动脉导管未闭风险的关系。材料和方法:本回顾性单中心队列研究分析了患者的医疗记录。根据有无症状性动脉导管未闭将新生儿分为两组。人口统计因素包括性别、胎龄、出生类型、出生体重、多胎妊娠、导管闭合或手术结扎的医疗情况、住院时间、死亡率和新生儿结局。评估24小时龄血清镁水平与症状性动脉导管未闭及其他新生儿疾病风险的关系。结果:本研究发现症状性动脉导管未闭与血清镁水平无显著关系。此外,血清镁水平和动脉导管直径之间没有显著差异,也不需要对症状性动脉导管未闭进行药物或手术干预。然而,血清镁水平高于3 mg/dL的新生儿出现呼吸窘迫综合征的发生率明显更高。相反,支气管肺发育不良发生率明显低于对照组,差异均有统计学意义(p < 0.05)。结论:这些结果表明,虽然血清镁水平可能不是症状性动脉导管未闭的可靠标志,但它们可能在调节新生儿呼吸结局方面具有临床意义。需要进一步的研究来探索潜在的机制,并评估镁在新生儿发病率管理中的潜在治疗作用。
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来源期刊
Cardiology in the Young
Cardiology in the Young 医学-小儿科
CiteScore
1.70
自引率
10.00%
发文量
715
审稿时长
4-8 weeks
期刊介绍: Cardiology in the Young is devoted to cardiovascular issues affecting the young, and the older patient suffering the sequels of congenital heart disease, or other cardiac diseases acquired in childhood. The journal serves the interests of all professionals concerned with these topics. By design, the journal is international and multidisciplinary in its approach, and members of the editorial board take an active role in the its mission, helping to make it the essential journal in paediatric cardiology. All aspects of paediatric cardiology are covered within the journal. The content includes original articles, brief reports, editorials, reviews, and papers devoted to continuing professional development.
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