In vitro assessment of portable, domestic UV-C disinfection devices' effects on skin fibroblasts.

IF 1.6 4区医学 Q3 OPHTHALMOLOGY

Cutaneous and Ocular Toxicology Pub Date : 2025-05-10 DOI:10.1080/15569527.2025.2502426

Eleni Kardamila, Chara Almpani, Andreas Vitsos, Dimitra Ieronymaki, Aspasia Petri, Michail Ch Rallis

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引用次数: 0

Abstract

Purpose: Portable UV-C disinfection devices for domestic use have been widely commercially available since COVID-19 pandemic. Concerns regarding their safety have been expressed, while there is a lack of actual data regarding the health effects of commercial hand-held UV-C disinfection devices. Herein, the acute effects of two commercial UV-C devices for domestic disinfection are evaluated in vitro, under realistic exposure conditions.

Materials and methods: Skin cells were exposed to an LP-Hg wand and an LED disinfection device for 10s, 30s, 5, 10 and 15 min. The devices measured the erythema effective irradiance was 5 W m^-2. Cellular viability, oxidative stress, protein oxidation and lipid peroxidation were evaluated right after irradiation.

Results: A dose-dependent cellular viability decrease and oxidative stress, protein oxidation and lipid peroxidation increase were demonstrated, while the LP-Hg wand seemed to induce more severe effects than the LED. Lipid peroxidation has been shown to be the dominant photooxidation mechanism, even at a sublethal radiant exposure.

Conclusion: The results provide evidence regarding the cutaneous photodamaging effects of commercially available UV-C disinfection devices for domestic use at the cellular level, contributing to the UV-C disinfection devices' risk management.

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便携式、国产UV-C消毒装置对皮肤成纤维细胞影响的体外评价。

目的：自COVID-19大流行以来，家用便携式UV-C消毒装置已广泛商业化。有人对其安全性表示关切，同时缺乏关于商用手持UV-C消毒装置对健康影响的实际数据。本文在现实暴露条件下，对两种商用UV-C家用消毒装置的急性效果进行了体外评估。材料和方法：皮肤细胞在LP-Hg棒和LED消毒装置中分别暴露10s、30s、5、10和15min。该装置测量的红斑有效辐照度为5 W m-2。细胞活力、氧化应激、蛋白质氧化和脂质过氧化作用在照射后立即被评估。结果：细胞活力呈剂量依赖性下降，氧化应激、蛋白质氧化和脂质过氧化增加，而LP-Hg魔杖诱导的影响似乎比LED更严重。脂质过氧化已被证明是主要的光氧化机制，即使在亚致死辐射暴露。结论：本研究结果在细胞水平上证明了市售家用UV-C消毒装置对皮肤的光损伤作用，为UV-C消毒装置的风险管理提供了依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cutaneous and Ocular Toxicology 医学-毒理学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

1 months

期刊介绍： Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.