The effect of 0.5 mL mepivacaine administered as an abaxial sesamoid nerve block on lameness of horses with digital pain did not differ significantly from that of 2.5 mL of mepivacaine.
Robert C Cole, Fred J DeGraves, Jessica Brown, John Schumacher
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引用次数: 0
Abstract
Objective: To compare the effect of 2.5 mL 2% mepivacaine to the effect of 0.5 mL 2% mepivacaine administered over each palmar digital nerve, as an abaxial sesamoid nerve block (ASNB), to 6 horses lame because of naturally occurring digital pain.
Methods: In a crossover study design with 3 horses in each group, the trotting gait of the horses was analyzed with an inertial sensor-based, motion-analysis system (Q with Lameness Locator; Equinosis LLC) immediately before and after treatment with either 0.5 or 2.5 mL mepivacaine administered over each nerve near the base of the proximal sesamoid bone of the lame forelimb. The gait was reevaluated objectively at 5-minute intervals for 20 minutes. Treatments were administered 48 hours apart.
Results: Both treatments significantly reduced lameness scores at all evaluations, and the lameness scores did not differ significantly between the treatment groups.
Conclusions: The effect of 0.5 mL of 2% mepivacaine HCl administered over each palmar digital nerve as an ASNB on lameness caused by digital pain did not differ significantly from the effect of 2.5 mL.
Clinical relevance: The volume of a local anesthetic for an ASNB, adequate to ameliorate digital pain, is less than that commonly recommended. A lower volume might more specifically localize the site of pain to the digit, but this supposition remains to be investigated.
目的：比较2.5 mL 2%甲哌卡因与0.5 mL 2%甲哌卡因作为背籽神经阻滞（ASNB）对6匹因自然发生的指痛而跛足的马的效果。方法：采用交叉研究设计，每组3匹马，采用基于惯性传感器的运动分析系统(Q with Lameness Locator；在治疗前后立即使用0.5或2.5 mL甲哌卡因对跛前肢近端籽骨基部附近的每条神经施用。每隔5分钟对步态进行客观评价，每次20分钟。治疗间隔48小时。结果：两种治疗方法在所有评估中均显著降低了跛行评分，且两组之间的跛行评分无显著差异。结论：0.5 mL的2%盐酸甲哌卡因作为ASNB在每根掌指神经上施用，对指痛引起的跛行的效果与2.5 mL的效果没有显著差异。临床相关性：ASNB的局麻药量足以改善指痛，但少于通常推荐的量。较小的体积可能更具体地将疼痛部位定位于手指，但这种假设仍有待研究。
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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