Association of Decreased Fecal Microbiota Akkermansia with Increased High-Sensitivity C-Reactive Protein Levels in Patients with Unstable Angina.

IF 2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Yuan-Fan Yuan, Ji-Yu Zhang, Jia-Hao Xu, Xin-Yi Xia, Miao Yu, Ling-Feng Zha, De-Sheng Hu, Wei-Min Wang, Chao-Long Wang, Qing Wang, Chen Chen, Zhi-Lei Shan, Fen Yang, Xiang Cheng
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引用次数: 0

Abstract

Background and objective: Inflammation plays a pivotal role in the progression of coronary artery disease (CAD). High-sensitivity C-reactive protein (hsCRP) serves as a well-established biomarker for assessing cardiovascular inflammation risk. However, the specific intestinal microbiota alteration contributing to increased inflammation remains unclear. Therefore, the present study investigated the correlation between the intestinal microbiota and inflammation in patients with unstable angina (UA).

Methods: A cohort of 92 patients with UA was recruited for this study. The plasma hsCRP level was measured via a CardioPhase hsCRP assay, fecal samples were collected after admission, and 16S rRNA sequencing was conducted to identify the fecal microbial profile. The participants were classified into two groups according to the median hsCRP level (1.11 mg/L). The composition of the fecal microbiota was compared between patients with hsCRP ≥ 1.11 mg/L and those with hsCRP < 1.11 mg/L. Additionally, the correlations between the fecal microbiota and clinical characteristics were analyzed.

Results: A notable reduction in the relative abundance of Akkermansia was observed in patients with hsCRP ≥ 1.11 mg/L, whereas the diversity of the fecal microbiota was not significantly different between patients with hsCRP ≥ 1.11 mg/L and those with hsCRP < 1.11 mg/L. Furthermore, the abundance of Akkermansia was negatively correlated with hsCRP levels.

Conclusion: This study suggested a significant association between decreased levels of Akkermansia and inflammatory risk in patients with UA. These findings underscore the potential role of the intestinal microbiota in contributing to inflammation in UA patients. Further work is needed on the mechanism by which the microbiota contributes to inflammatory risk.

不稳定心绞痛患者粪便微生物群Akkermansia减少与高敏c反应蛋白水平升高的关系
背景与目的:炎症在冠状动脉疾病(CAD)的进展中起着关键作用。高灵敏度c反应蛋白(hsCRP)是一种公认的评估心血管炎症风险的生物标志物。然而,导致炎症增加的特定肠道微生物群改变尚不清楚。因此,本研究探讨了不稳定型心绞痛(UA)患者肠道菌群与炎症的相关性。方法:本研究招募了92例UA患者。通过cardiphase hsCRP检测测定血浆hsCRP水平,入院后收集粪便样本,并进行16S rRNA测序以鉴定粪便微生物谱。根据中位hsCRP水平(1.11 mg/L)将参与者分为两组。比较hsCRP≥1.11 mg/L患者与hsCRP患者粪便菌群组成结果:hsCRP≥1.11 mg/L患者Akkermansia菌群相对丰度显著降低,而hsCRP≥1.11 mg/L患者与hsCRP患者粪便菌群多样性无显著差异。该研究表明,UA患者Akkermansia水平降低与炎症风险之间存在显著关联。这些发现强调了肠道微生物群在UA患者炎症中的潜在作用。需要进一步研究微生物群增加炎症风险的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Medical Science
Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
4.70
自引率
0.00%
发文量
126
期刊介绍: Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.
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