Lactate dehydrogenase (LDH) as an indicator of pre-eclampsia.

Abstract

High blood pressure (higher than 140/90 mm Hg), proteinuria and swelling due to fluid retention are symptoms of preeclampsia, a disease that affects pregnant women after the 20th week of pregnancy. The cytoplasm of cells undergoing anaerobic glycolysis contains the enzyme lactate dehydrogenase or LDH. Therefore, it is of interest to ascertain the blood lactate dehydrogenase levels of pre-eclamptic women, to assess and analyze these levels, to compare lactate dehydrogenase levels in different groups of preeclampsia patients and healthy controls and to examine the role of lactate dehydrogenase in preeclampsia severity ratings. Increased blood lactate dehydrogenase levels are associated with more severe preeclampsia, according to this study's results. Thus, it is crucial to determine lactate dehydrogenase levels in pre-eclamptic women early on so that these patients may get the right medicine and reduce the morbidity and mortality associated with these disorders.