{"title":"A gut-wrenching tale of neuronal distress.","authors":"Murillo Duarte-Silva, Meenakshi Rao","doi":"10.1016/j.neuron.2025.03.033","DOIUrl":null,"url":null,"abstract":"<p><p>Neurons innervating the gut are on the frontlines of host-microbe interactions and thus exposed to a myriad of inflammatory and infectious insults. In this issue of Neuron, Forster, Jakob et al.<sup>1</sup> reveal that diverse populations of gut-innervating neurons exhibit conserved responses to inflammation, linking interferon signaling to ferroptosis.</p>","PeriodicalId":19313,"journal":{"name":"Neuron","volume":"113 9","pages":"1291-1293"},"PeriodicalIF":14.7000,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.neuron.2025.03.033","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Neurons innervating the gut are on the frontlines of host-microbe interactions and thus exposed to a myriad of inflammatory and infectious insults. In this issue of Neuron, Forster, Jakob et al.1 reveal that diverse populations of gut-innervating neurons exhibit conserved responses to inflammation, linking interferon signaling to ferroptosis.
期刊介绍:
Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.