Analysis of multichannel intraluminal impedance and pH monitoring values in children with cerebral palsy: A comparative multicenter study.

IF 2.4 3区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Cristina Lorenzo, Cecilia Zubiri, Anabella Zosi, Sandro Miculan, Daniela Neder, Ana Rocca, Judith Cohen Sabban, Roman Bigliardi, Maria Florencia Biasoli, Manuela Manterola, Maria de Los Angeles Savia, Luis Orlando Perez, Carlos Ruiz Hernández, Renata Weinschelbaum, Ana Cristina Fontenele Soares, Soraia Tahan, Veronica Plante, Christian Boggio, Soledad Arcucci, Erick Toro Monjaraz, Maria Alejandra Mortarini, Samantha Arrizabalo, Miguel Saps
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引用次数: 0

Abstract

Objectives: To compare the features of multichannel intraluminal impedance and pH monitoring (MII-pH) tracings in children with cerebral palsy (CP) and children without CP.

Methods: Multicenter, retrospective, analytical study. We examined tracings of children aged 1 to 15 years old, evaluated from May 2017 to January 2024. Population included two groups: Group 1 consisted of children with CP, while control group comprised children without CP who had extra-digestive symptoms suggestive of gastroesophageal reflux disease (GERD) but normal MII-pH results. Quantitative data were analyzed using analysis of variance and t tests. Qualitative data were analyzed using contingency tables and chi-square tests.

Results: We studied 245 children. CP group included 110 children with a mean age of 5.71 years (standard deviation [SD] ± 4.24), while control group included 135 children with a mean age of 5.73 years (SD ± 3.39). The CP group had fewer reflux episodes (p = 0.0015), slower mean acid clearance time (p = 0.04), lower mean baseline impedance and mean nocturnal baseline impedance (p = 1.82e-07 and p = 7.50e-07).

Conclusion: Children with CP have fewer reflux episodes and longer acid clearance times compared with children without CP. Prospective studies including esophagogastroduodenoscopy findings are needed to establish MII-pH reference values in children with CP.

脑瘫患儿多通道腔内阻抗及pH监测值分析:一项多中心比较研究。
目的:比较脑瘫(CP)患儿与非CP患儿多通道腔内阻抗及pH监测(MII-pH)的特点。方法:采用多中心回顾性分析研究。我们检查了从2017年5月到2024年1月评估的1至15岁儿童的追踪。人群包括两组:第一组为患有CP的儿童,而对照组为没有CP的儿童,他们有胃食管反流病(GERD)的额外消化症状,但MII-pH结果正常。定量资料采用方差分析和t检验进行分析。定性资料采用列联表和卡方检验进行分析。结果:我们研究了245名儿童。CP组患儿110例,平均年龄5.71岁(标准差[SD]±4.24),对照组患儿135例,平均年龄5.73岁(SD±3.39)。CP组反流发作次数较少(p = 0.0015),平均酸清除时间较慢(p = 0.04),平均基线阻抗和平均夜间基线阻抗较低(p = 1.82e-07和p = 7.50e-07)。结论:与无CP的儿童相比,CP儿童的反流发作较少,酸清除时间更长。需要前瞻性研究,包括食管胃十二指肠镜检查结果,以确定CP儿童的MII-pH参考值。
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来源期刊
CiteScore
5.30
自引率
13.80%
发文量
467
审稿时长
3-6 weeks
期刊介绍: ​The Journal of Pediatric Gastroenterology and Nutrition (JPGN) provides a forum for original papers and reviews dealing with pediatric gastroenterology and nutrition, including normal and abnormal functions of the alimentary tract and its associated organs, including the salivary glands, pancreas, gallbladder, and liver. Particular emphasis is on development and its relation to infant and childhood nutrition.
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