Exploring the Role of Long Non-Coding RNAs in Mediating Cisplatin Resistance in Colorectal Cancer.

IF 2.3 4区 医学 Q3 ONCOLOGY
Shirin Azizidoost, Omid Anbiyaee, Atefeh Bahmani, Maryam Khombi Shooshtari, Pezhman Alavinejad, Sara Zarasvandnia, Maryam Farzaneh
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引用次数: 0

Abstract

Colorectal cancer (CRC) usually begins as adenomatous polyps in the colorectal or rectal epithelial cells. Currently, there are no reliable biomarkers for early CRC screening or prognostic prediction, leading to late-stage diagnoses when surgical options may no longer be viable. The disease is driven by mutations in oncogenes, tumor suppressor genes, and DNA repair genes, with rapid growth and metastasis contributing to treatment failure. Over the past two decades, research on non-coding RNAs (ncRNAs), particularly long ncRNAs (lncRNAs), has expanded significantly, revealing their critical roles in cancer biology. LncRNAs are involved in numerous biological processes such as cell proliferation, apoptosis, metabolism, and drug resistance, and they are often abnormally expressed in various cancers, including hepatocellular carcinoma, pancreatic cancer, and bladder cancer. In CRC, lncRNAs play a regulatory role by influencing cell cycle, proliferation, apoptosis, and epithelial-mesenchymal transition, and some have been shown to affect CRC cell proliferation, invasion, and resistance to cisplatin, highlighting their potential as therapeutic targets and biomarkers in cancer treatment. This review highlights current investigations on the functions and mechanisms of lncRNAs in cisplatin resistance in CRC. Such overview is anticipated to contribute to figuring out that lncRNAs can be applied as a promising target gene to develop drug resistance and remedial efficacy.

探索长链非编码rna在结直肠癌顺铂耐药中的作用。
结直肠癌(CRC)通常起源于结直肠或直肠上皮细胞的腺瘤性息肉。目前,没有可靠的生物标志物用于早期CRC筛查或预后预测,导致晚期诊断,手术选择可能不再可行。该疾病是由癌基因、肿瘤抑制基因和DNA修复基因的突变驱动的,其快速生长和转移导致治疗失败。在过去的二十年中,对非编码rna (ncRNAs),特别是长链ncRNAs (lncRNAs)的研究得到了显著的扩展,揭示了它们在癌症生物学中的关键作用。LncRNAs参与细胞增殖、凋亡、代谢、耐药等多种生物学过程,在肝癌、胰腺癌、膀胱癌等多种癌症中均有异常表达。在结直肠癌中,lncrna通过影响细胞周期、增殖、凋亡和上皮-间质转化发挥调节作用,其中一些lncrna已被证明影响结直肠癌细胞的增殖、侵袭和对顺铂的耐药性,突出了其作为癌症治疗靶点和生物标志物的潜力。本文综述了lncrna在结直肠癌顺铂耐药中的作用和机制。这一综述有望帮助我们发现lncRNAs可以作为一种有前景的靶基因来开发耐药和治疗疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current cancer drug targets
Current cancer drug targets 医学-肿瘤学
CiteScore
5.40
自引率
0.00%
发文量
105
审稿时长
1 months
期刊介绍: Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.
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