Advances in targeted therapy for inflammatory breast cancer: nanomaterials, conventional treatments, and clinical applications.

IF 2.9 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nanotechnology Pub Date : 2025-05-13 DOI:10.1088/1361-6528/add165

Eshana Bhattacharya, Siuli Shaw, Ranu Nayak, Sudeep Bose

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引用次数: 0

Abstract

Inflammatory breast cancer (IBC) presents a formidable challenge due to its rapid progression and unique clinical characteristics within the various manifestations of breast cancer. Despite being rare, its aggressive nature demands innovative approaches beyond conventional treatments. Nanomedicine offers exciting possibilities for improving all types of breast cancer therapeutics including IBC. In this review, we critically assess the current treatment landscape for IBC, highlighting the limitations of traditional methods and addressing the pressing need for new therapeutic strategies. Although many nanomaterials have been explored for breast cancer therapeutics, either alone or in combination with other therapies, only a limited number of nanotherapeutics have been extensively studied for IBC treatment. This review further explores how advancements in nanotechnology, such as nanoparticle- mediated photothermal therapy, Photodynamic therapy, and nanomedicinal targeted therapies can offer novel avenues for addressing the unique biological, technological, and regulatory challenges posed by IBC. IBC-related various nanomedicines based combinatorial therapies are highlighted in this review. It also provides a forward-looking perspective on key research directions and clinical applications.

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炎性乳腺癌靶向治疗的进展：纳米材料、常规治疗和临床应用。

炎症性乳腺癌（IBC）由于其快速发展和独特的临床特点，在乳腺癌的各种表现中提出了一个巨大的挑战。尽管它很罕见，但它的侵袭性需要传统治疗之外的创新方法。纳米医学为改善包括IBC在内的所有类型的乳腺癌治疗提供了令人兴奋的可能性。在这篇综述中，我们批判性地评估了目前IBC的治疗前景，强调了传统方法的局限性，并解决了对新治疗策略的迫切需求。尽管已经探索了许多纳米材料用于乳腺癌治疗，无论是单独使用还是与其他疗法联合使用，但只有有限数量的纳米疗法被广泛研究用于IBC治疗。这篇综述进一步探讨了纳米技术的进步，如纳米粒子介导的光热疗法、光动力疗法和纳米药物靶向疗法，如何为解决IBC带来的独特的生物、技术和监管挑战提供新的途径。本文综述了与ibc相关的各种基于纳米药物的组合疗法。为重点研究方向和临床应用提供前瞻性视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanotechnology 工程技术-材料科学：综合

CiteScore

7.10

自引率

5.70%

发文量

820

审稿时长

2.5 months

期刊介绍： The journal aims to publish papers at the forefront of nanoscale science and technology and especially those of an interdisciplinary nature. Here, nanotechnology is taken to include the ability to individually address, control, and modify structures, materials and devices with nanometre precision, and the synthesis of such structures into systems of micro- and macroscopic dimensions such as MEMS based devices. It encompasses the understanding of the fundamental physics, chemistry, biology and technology of nanometre-scale objects and how such objects can be used in the areas of computation, sensors, nanostructured materials and nano-biotechnology.