3D Computational Modeling of Fe3O4@Au Nanoparticles in Hyperthermia Treatment of Skin Cancer.

IF 4.9 Q2 NANOSCIENCE & NANOTECHNOLOGY
Nanotechnology, Science and Applications Pub Date : 2025-04-12 eCollection Date: 2025-01-01 DOI:10.2147/NSA.S495377
Piotr Gas, Muhammad Suleman, Farah Khaliq
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引用次数: 0

Abstract

Background: Nanotechnology can be used to treat a diversity of cancers with different physiological properties. Skin cancers are common among people affected by an excessive solar radiation of the ultraviolet (UV) range.

Introduction: This paper describes a mathematical formulation and simulation approach for the magnetic hyperthermia therapy of skin cancer using gold-coated iron oxide (Fe3O4@Au) magnetic nanoparticles (MNPs).

Methods: The authors created an artificial 3D geometry model of skin cancer with tissue-mimicking materials, constructed a mesh, and solved all the required physics for electro-thermal simulation using FEM-based software. The heat transfer in the skin tissue was modeled using the Pennes bioheat equation, and the Helmholtz-type equation of quasi-static magnetic field produced by a three-turned coil surrounding the tumor.

Results: The simulated magnetic field pattern was compared with that of the analytical solution along the symmetry axis of the helical coil with good agreement. The obtained results show that the tumor damage is maximum in the tumor center and decreases towards its outer boundaries. Additionally, the impact of varying values of blood perfusion rate, blood density, blood specific heat capacity, heat dissipation produced by Fe3O4@Au MNPs, and metabolic heat generation has been examined for thermal therapy. The performed simulations show that all these parameters influences heating characteristics of tumor tissues by gold-coated magnetic nanoparticles.

Conclusion: Gold-iron oxide magnetic nanoparticles succeeded to damage 90-99% skin cancer. Among all the contributing parameters, the blood perfusion is the most sensitive parameter in thermal therapy of skin tumor.

Recommendations: On the bases of results obtained, we recommend physicians to use Fe3O4@Au MNPs in real time medical skin cancer treatments.

Fe3O4@Au纳米粒子在皮肤癌热疗中的三维计算模型。
背景:纳米技术可用于治疗多种具有不同生理特性的癌症。皮肤癌在受紫外线(UV)范围的过度太阳辐射影响的人群中很常见。本文描述了一种利用金包氧化铁(Fe3O4@Au)磁性纳米颗粒(MNPs)进行皮肤癌磁热疗的数学公式和模拟方法。方法:采用组织模拟材料,建立人工皮肤癌三维几何模型,构建网格,利用有限元软件求解电热模拟所需的所有物理问题。采用Pennes生物热方程和helmholtz型准静态磁场方程对皮肤组织内的热传递进行了建模,准静态磁场由肿瘤周围的三匝线圈产生。结果:模拟的磁场图与解析解沿螺旋线圈对称轴方向的磁场图吻合较好。结果表明:肿瘤中心损伤最大,向外边界损伤减小;此外,还研究了不同的血液灌注率、血液密度、血液比热容、Fe3O4@Au MNPs产生的散热和代谢热产生的影响。模拟结果表明,这些参数都影响了包金磁性纳米颗粒对肿瘤组织的加热特性。结论:金氧化铁磁性纳米颗粒对皮肤癌的损伤率达到90 ~ 99%。在所有相关参数中,血液灌注是皮肤肿瘤热疗中最敏感的参数。建议:根据获得的结果,我们建议医生在实时医学皮肤癌治疗中使用Fe3O4@Au MNPs。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nanotechnology, Science and Applications
Nanotechnology, Science and Applications NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
11.70
自引率
0.00%
发文量
3
审稿时长
16 weeks
期刊介绍: Nanotechnology, Science and Applications is an international, peer-reviewed, Open Access journal that focuses on the science of nanotechnology in a wide range of industrial and academic applications. The journal is characterized by the rapid reporting of reviews, original research, and application studies across all sectors, including engineering, optics, bio-medicine, cosmetics, textiles, resource sustainability and science. Applied research into nano-materials, particles, nano-structures and fabrication, diagnostics and analytics, drug delivery and toxicology constitute the primary direction of the journal.
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