Shiqing Xiang, Yi Jiang, Fangxiang Mu, Hong Wu, Nian Zhang
{"title":"A Systematic Review of Mendelian Randomization in Spontaneous Miscarriage.","authors":"Shiqing Xiang, Yi Jiang, Fangxiang Mu, Hong Wu, Nian Zhang","doi":"10.2147/JMDH.S515367","DOIUrl":null,"url":null,"abstract":"<p><p>Spontaneous miscarriage (SM) is a common pregnancy complication. Although clinical factors are associated with SM, establishing causality is challenging. Mendelian randomization (MR) helps evaluate the causal effects of exposure variables. This study systematically reviewed 31 MR studies performed in SM, identifying causal relationships between SM and smoking, obesity, insomnia, rheumatoid arthritis, and immune-related factors. Smoking initiation and insomnia were identified as risk factors for SM. Coffee consumption showed no causal association with SM risk. Inconsistent evidence was reported for alcohol intake, BMI, depression, and RA regarding their causal relationships with SM. Smoking initiation, specific cytokines (eg, IL-12, TNF-β), and immune cells (eg, CD4+ T cells) demonstrated causal associations with the number of SM. Notably, key SNPs like rs13261666 and rs7127595 played significant roles in MR analyses due to their strong genetic associations with risk factors. Future research should further investigate the mechanistic pathways linking these genetic variants to SM, aiming to provide precise guidance for clinical prevention and treatment. Additionally, inconsistencies in MR results may stem from differences in data sources, SNP selection criteria, and statistical methodologies, indicating the importance of improving data consistency and standardizing analytical approaches in future research.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"2237-2246"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12025826/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Multidisciplinary Healthcare","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JMDH.S515367","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0
Abstract
Spontaneous miscarriage (SM) is a common pregnancy complication. Although clinical factors are associated with SM, establishing causality is challenging. Mendelian randomization (MR) helps evaluate the causal effects of exposure variables. This study systematically reviewed 31 MR studies performed in SM, identifying causal relationships between SM and smoking, obesity, insomnia, rheumatoid arthritis, and immune-related factors. Smoking initiation and insomnia were identified as risk factors for SM. Coffee consumption showed no causal association with SM risk. Inconsistent evidence was reported for alcohol intake, BMI, depression, and RA regarding their causal relationships with SM. Smoking initiation, specific cytokines (eg, IL-12, TNF-β), and immune cells (eg, CD4+ T cells) demonstrated causal associations with the number of SM. Notably, key SNPs like rs13261666 and rs7127595 played significant roles in MR analyses due to their strong genetic associations with risk factors. Future research should further investigate the mechanistic pathways linking these genetic variants to SM, aiming to provide precise guidance for clinical prevention and treatment. Additionally, inconsistencies in MR results may stem from differences in data sources, SNP selection criteria, and statistical methodologies, indicating the importance of improving data consistency and standardizing analytical approaches in future research.
期刊介绍:
The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.