A Systematic Review of Mendelian Randomization in Spontaneous Miscarriage.

IF 2.7 3区 医学 Q2 HEALTH CARE SCIENCES & SERVICES
Journal of Multidisciplinary Healthcare Pub Date : 2025-04-21 eCollection Date: 2025-01-01 DOI:10.2147/JMDH.S515367
Shiqing Xiang, Yi Jiang, Fangxiang Mu, Hong Wu, Nian Zhang
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引用次数: 0

Abstract

Spontaneous miscarriage (SM) is a common pregnancy complication. Although clinical factors are associated with SM, establishing causality is challenging. Mendelian randomization (MR) helps evaluate the causal effects of exposure variables. This study systematically reviewed 31 MR studies performed in SM, identifying causal relationships between SM and smoking, obesity, insomnia, rheumatoid arthritis, and immune-related factors. Smoking initiation and insomnia were identified as risk factors for SM. Coffee consumption showed no causal association with SM risk. Inconsistent evidence was reported for alcohol intake, BMI, depression, and RA regarding their causal relationships with SM. Smoking initiation, specific cytokines (eg, IL-12, TNF-β), and immune cells (eg, CD4+ T cells) demonstrated causal associations with the number of SM. Notably, key SNPs like rs13261666 and rs7127595 played significant roles in MR analyses due to their strong genetic associations with risk factors. Future research should further investigate the mechanistic pathways linking these genetic variants to SM, aiming to provide precise guidance for clinical prevention and treatment. Additionally, inconsistencies in MR results may stem from differences in data sources, SNP selection criteria, and statistical methodologies, indicating the importance of improving data consistency and standardizing analytical approaches in future research.

孟德尔随机化在自然流产中的系统评价。
自然流产是一种常见的妊娠并发症。虽然临床因素与SM有关,但建立因果关系是具有挑战性的。孟德尔随机化(MR)有助于评估暴露变量的因果效应。本研究系统回顾了31项针对SM的MR研究,确定了SM与吸烟、肥胖、失眠、类风湿关节炎和免疫相关因素之间的因果关系。开始吸烟和失眠被确定为SM的危险因素。咖啡摄入与SM风险没有因果关系。关于酒精摄入、BMI、抑郁和RA与SM的因果关系,有不一致的证据报道。吸烟起始、特定细胞因子(如IL-12、TNF-β)和免疫细胞(如CD4+ T细胞)与SM的数量有因果关系。值得注意的是,rs13261666和rs7127595等关键snp由于其与危险因素的强烈遗传关联,在MR分析中发挥了重要作用。未来的研究应进一步探索这些遗传变异与SM的机制通路,为临床预防和治疗提供精确的指导。此外,MR结果的不一致可能源于数据源、SNP选择标准和统计方法的差异,这表明在未来的研究中提高数据一致性和标准化分析方法的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Multidisciplinary Healthcare
Journal of Multidisciplinary Healthcare Nursing-General Nursing
CiteScore
4.60
自引率
3.00%
发文量
287
审稿时长
16 weeks
期刊介绍: The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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