Survival Outcomes of Preoperative Serum Biomarkers in Patients With Surgically Treated Intrahepatic Cholangiocarcinoma.

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-04-18 eCollection Date: 2025-06-01 DOI:10.14309/ctg.0000000000000845

Di Zeng, Shaofeng Wang, Nansheng Cheng, Geng Liu, Bei Li

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引用次数: 0

Abstract

Introduction: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor, often diagnosed at advanced stages, with recurrence and metastasis significantly affecting survival. The combined prognostic value of biomarkers such as the Systemic Immune-Inflammation Index (SII), Fibrosis-4 (FIB-4), and Prognostic Nutritional Index (PNI) remains underexplored.

Methods: A retrospective analysis of 280 patients with ICC who underwent curative resection was performed. The prognostic significance of FIB-4, SII, and PNI for overall survival (OS) and disease-free survival (DFS) was assessed using clinical, pathological, and follow-up data. Statistical analysis included Cox regression and Kaplan-Meier survival curves.

Results: High PNI was significantly associated with better OS ( P = 0.014) and DFS ( P = 0.025). High FIB-4 levels correlated with worse OS ( P = 0.0076) and DFS ( P = 0.023). High SII was strongly associated with poor OS ( P < 0.0001) and DFS ( P = 0.00041). The combination of high SII, low PNI, and high FIB-4 was linked to significantly worse OS (hazard ratios = 2.633, P = 0.002) and DFS (hazard ratios = 2.475, P = 0.004).

Discussion: Preoperative serum biomarkers, including PNI, FIB-4, and SII, are significant independent prognostic factors for patients with ICC. Their combined use may help refine prognostic assessment and guide personalized treatment strategies.

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手术治疗肝内胆管癌患者术前血清生物标志物的生存结局。

背景：肝内胆管癌（ICC）是一种高度恶性肿瘤，常在晚期诊断，复发和转移严重影响生存。诸如系统性免疫炎症指数（SII）、纤维化-4指数（FIB-4）和预后营养指数（PNI）等生物标志物的综合预后价值仍未得到充分研究。方法：对280例行根治性手术的ICC患者进行回顾性分析。通过临床、病理和随访数据评估FIB-4、SII和PNI对总生存期（OS）和无病生存期（DFS）的预后意义。统计学分析采用Cox回归和Kaplan-Meier生存曲线。结果：高PNI与较好的OS （P = 0.014）和DFS （P = 0.025）显著相关。高FIB-4水平与较差的OS （P = 0.0076）和DFS （P = 0.023）相关。高SII与较差的OS （P < 0.0001）和DFS （P = 0.00041）密切相关。高SII、低PNI和高FIB-4的组合与较差的OS （HR = 2.633, P = 0.002）和DFS （HR = 2.475, P = 0.004）显著相关。讨论：术前血清生物标志物，包括PNI、FIB-4和SII，是ICC患者重要的独立预后因素。他们的联合使用可能有助于完善预后评估和指导个性化的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.