Association between SARS-CoV-2 viral load and serum biomarkers with mortality in Mexican patients.

IF 1.4 Q3 EDUCATION, SCIENTIFIC DISCIPLINES

Journal of Education and Health Promotion Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI:10.4103/jehp.jehp_1481_24

Dulce M Razo-Blanco-Hernández, José Á Hernández-Mariano, Mónica A Díaz-Cureño, Lenny Navarrete-Martínez, Juan C Bravata-Alcántara, Roberto Rivera-Sanchez, Verónica Fernandez-Sánchez

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引用次数: 0

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has resulted in high mortality among hospitalized patients; thus, identifying mortality markers in treating these patients is essential. To evaluate the association between viral load and serum biomarkers with mortality among hospitalized patients with COVID-19.

Materials and methods: A retrospective cohort study was conducted among 198 inpatient records from a tertiary hospital in Mexico City between January and April 2021. The association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load and serum biomarkers with death due to COVID-19 was assessed using Cox regression models.

Results: The median age was 54.9 years, and 61.6% were males. The mortality rate was 43.4%. After adjusting for potential confounders, patients with higher viral load [adjusted hazard ratio (aHR) = 1.56; 95% confidence interval (95% CI) = 1.01, 2.42; P value = 0.041]; and higher concentrations of BUN (aHR = 4.87;95% CI = 2.70, 8.79; P value = 0.001), creatinine (aHR = 1.60;95% CI = 1.01, 2.54; P value = 0.043), osmolality (aHR = 4.37;95% CI = 2.34, 8.14; P value = 0.001), and glucose (aHR = 2.41;95% CI = 1.40, 4.18; P value = 0.001) were more likely to have a fatal prognosis. Conversely, mortality risk was lower among patients with high concentrations of lymphocytes (aHR = 0.47;95% CI = 0.30, 0.72; P value = 0.001).

Conclusion: SARS-CoV-2 viral load and serum biomarkers such as BUN, creatinine, glucose, osmolarity, and lymphocytes could help physicians identify individuals who require closer monitoring.

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墨西哥患者SARS-CoV-2病毒载量和血清生物标志物与死亡率的关系

背景：2019冠状病毒病（COVID-19）大流行导致住院患者死亡率高；因此，在治疗这些患者时，确定死亡率标志是至关重要的。评估COVID-19住院患者病毒载量和血清生物标志物与死亡率的关系。材料和方法：对2021年1月至4月期间墨西哥城一家三级医院的198例住院患者进行回顾性队列研究。使用Cox回归模型评估严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）病毒载量与血清生物标志物与COVID-19死亡之间的关系。结果：中位年龄54.9岁，男性占61.6%。死亡率为43.4%。在对潜在混杂因素进行校正后，病毒载量较高的患者[校正风险比(aHR) = 1.56；95%置信区间(95% CI) = 1.01, 2.42；P值= 0.041]；较高浓度的BUN (aHR = 4.87;95% CI = 2.70, 8.79；P值= 0.001)、肌酐(aHR = 1.60;95% CI = 1.01, 2.54；P值= 0.043)、渗透压(aHR = 4.37;95% CI = 2.34, 8.14；P值= 0.001)，葡萄糖(aHR = 2.41;95% CI = 1.40, 4.18；P值= 0.001)更可能有致命的预后。相反，淋巴细胞浓度高的患者死亡风险较低(aHR = 0.47;95% CI = 0.30, 0.72；P值= 0.001)。结论：SARS-CoV-2病毒载量和血清生物标志物如BUN、肌酐、葡萄糖、渗透压和淋巴细胞可以帮助医生识别需要密切监测的个体。

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