Gut microbiome composition and one-year survival outcomes among patients with reduced ejection fraction heart failure.

IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiology Pub Date : 2025-04-22 DOI:10.1159/000545877
Seyed Mohsen Mirhosseini, Mahdi Rezaei, Masood Soltanipur, Hossein Yarmohammadi, Erfan Soroush, Amirmahdi Taromiha, Nayere Ebrahimzadeh, Ali Nour Neamatollahi, Abolfazl Fateh, Fatemeh Hatefi, Delaram Douroud, Jafar Panahi, Sepideh Jafari Naeini, Seyed Davar Siadat
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引用次数: 0

Abstract

Background: Imbalances in gut microbiota are linked to chronic diseases, including heart failure, where shifts in microbial composition are evident in patients with reduced ejection fraction (HFrEF). This study compared gut microbiome profiles between HFrEF patients and healthy controls and explored potential links between microbiome composition and patient survival over 6 and 12 months.

Methods: In this longitudinal case-control study, 20 HFrEF patients and 40 healthy controls were recruited, with stool samples collected for gut microbiome analysis. Patients were followed for six and twelve months to assess survival. Gut microbiome composition was analyzed using real-time PCR for specific bacterial taxa. Statistical analyses were performed using R to compare HFrEF and control groups and draw the ROC curve to predict survival at six and twelve months.

Results: HFrEF patients showed a significantly lower abundance of all bacterial taxa, except for A. muciniphila. Decreased levels of Prevotella, F. prausnitzii, Firmicutes, and Bacteroides, as well as a lower Firmicutes/Bacteroidetes (F/B) ratio, were notable in HFrEF patients, with specific taxa correlating with clinical features like ascites and vitamin D levels. Most bacterial taxa and the F/B ratio could distinguish HFrEF patients from controls, though none effectively predicted survival outcomes at six or twelve months.

Conclusion: The study demonstrates that patients with HFrEF exhibit a distinct gut microbiome profile compared to healthy individuals. While specific gut bacteria were effective in distinguishing HFrEF patients from healthy controls, their ability to predict survival outcomes was limited, highlighting the need for further research into the role of the gut microbiome in the progression and prognosis of heart failure.

低射血分数心力衰竭患者的肠道微生物组成和一年生存结局。
背景:肠道微生物群失衡与慢性疾病有关,包括心力衰竭,其中微生物组成的变化在射血分数(HFrEF)降低的患者中很明显。本研究比较了HFrEF患者和健康对照者的肠道微生物群特征,并探讨了微生物群组成与患者6个月和12个月生存率之间的潜在联系。方法:在这项纵向病例对照研究中,招募了20名HFrEF患者和40名健康对照者,收集粪便样本进行肠道微生物组分析。随访患者6个月和12个月以评估生存率。采用实时荧光定量PCR技术分析肠道微生物组组成。采用R进行统计学分析,比较HFrEF组和对照组,绘制ROC曲线预测6个月和12个月的生存率。结果:HFrEF患者除嗜粘液芽胞杆菌外,其余细菌群丰度均显著降低。在HFrEF患者中,Prevotella、F. prausnitzii、厚壁菌门和拟杆菌门的水平降低,以及厚壁菌门/拟杆菌门(F/B)的比例降低是显著的,具体的分类群与腹水和维生素D水平等临床特征相关。大多数细菌分类和F/B比值可以区分HFrEF患者和对照组,尽管没有一个能有效预测6个月或12个月的生存结果。结论:该研究表明,与健康个体相比,HFrEF患者表现出不同的肠道微生物群特征。虽然特定的肠道细菌可以有效地区分HFrEF患者和健康对照组,但它们预测生存结果的能力有限,这表明需要进一步研究肠道微生物群在心力衰竭进展和预后中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cardiology
Cardiology 医学-心血管系统
CiteScore
3.40
自引率
5.30%
发文量
56
审稿时长
1.5 months
期刊介绍: ''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.
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