Multisite Chronic Pain and the Risk of Breast Cancer and Its Subtypes: A Mendelian Randomization Study.

IF 2.5 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Pain Research Pub Date : 2025-05-07 eCollection Date: 2025-01-01 DOI:10.2147/JPR.S489703

Wanyu Li, Jintao Liu, Teng Wang, Yudong Hou, Jianheng Bao, Yanyan Song, Longbi Liu, Shuke Ge, Yaohua Shang, Rongdi Wang, Min Zhang, Meng Xu

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引用次数: 0

Abstract

Background: Chronic pain (CP) is widespread and a major cause of disability. However, its genetic and environmental risk factors, as well as its relationship with breast cancer (BC), remain unclear. The study is the first to apply Mendelian randomization (MR) to explore the causal relationship between CP and BC.

Methods: Two-sample MR and multivariable MR (MVMR) were performed using genome-wide association study (GWAS) data. Univariable MR assessed the effect of CP on BC, while MVMR adjusted for body mass index (BMI). The inverse variance-weighted method was used as the primary method.

Results: Univariable MR found a strong genetic link between stomach/abdominal pain and overall BC risk (OR 3.411, 95% CI 1.029-11.313, P=0.045). Neck/shoulder pain was associated with Luminal_A breast cancer risk (OR 1.999, 95% CI 1.263-3.163, P=0.003). Multivariable MR, adjusting for BMI, confirmed these findings for stomach/abdominal pain to overall BC (OR 4.39, 95% CI 1.48-13.06, P=0.008) and neck/shoulder pain to Luminal_A BC (OR 2.46, 95% CI 1.24-4.87, P=0.010). No associations were found for other pain types (headache, hip pain, back pain, knee pain, facial pain) with BC subtypes.

Conclusion: Genetic evidence in this study suggests a causal link between stomach/abdominal pain and overall BC, and between neck/shoulder pain and Luminal-A BC risk in Europeans. Determining the cause of this discrepancy might shed light on the complicated link between breast cancer etiology and chronic pain genetics, emphasizing the need for further investigations and potential clinical applications to enhance breast cancer prevention and management.

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多部位慢性疼痛与乳腺癌及其亚型的风险：孟德尔随机研究。

背景：慢性疼痛（CP）广泛存在，是致残的主要原因。然而，其遗传和环境风险因素以及与乳腺癌（BC）的关系尚不清楚。该研究首次应用孟德尔随机化（MR）来探讨CP和BC之间的因果关系。方法：采用全基因组关联研究（GWAS）数据进行双样本MR和多变量MR （MVMR）。单变量MR评估CP对BC的影响，而MVMR调整体重指数（BMI）。采用方差加权逆法作为主要方法。结果：单变量MR发现胃/腹痛与总体BC风险之间存在很强的遗传联系（OR 3.411, 95% CI 1.029-11.313， P=0.045）。颈部/肩部疼痛与Luminal_A乳腺癌风险相关（OR 1.999, 95% CI 1.263-3.163， P=0.003）。调整BMI后的多变量MR证实了胃痛/腹痛与总体BC （OR 4.39, 95% CI 1.48-13.06， P=0.008）和颈/肩痛与Luminal_A BC （OR 2.46, 95% CI 1.24-4.87， P=0.010）的相关性。其他类型的疼痛（头痛、髋部疼痛、背部疼痛、膝盖疼痛、面部疼痛）与BC亚型没有关联。结论：本研究的遗传证据表明，欧洲人胃痛/腹痛与整体BC之间存在因果关系，颈/肩痛与Luminal-A BC风险之间存在因果关系。确定这种差异的原因可能会揭示乳腺癌病因学和慢性疼痛遗传学之间的复杂联系，强调需要进一步研究和潜在的临床应用，以加强乳腺癌的预防和管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pain Research CLINICAL NEUROLOGY-

CiteScore

4.50

自引率

3.70%

发文量

411

审稿时长

16 weeks

期刊介绍： Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.