Efficacy of nonsurgical periodontal treatment on patients with periodontitis and type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Acta Odontologica Scandinavica Pub Date : 2025-05-13 DOI:10.2340/aos.v84.43344

Xuejie Xie, Jun Xu, Yiming Li, Li Tang, Gulinuer Awuti

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Abstract

Objective: This study aimed to evaluate the effects of periodontal basic therapy combined with various adjunctive treatments on periodontal inflammation and glycemic control in patients with periodontitis and type 2 diabetes mellitus (T2DM) using network meta-analysis.

Methods: Randomized controlled trials (RCTs) involving patients with periodontitis and T2DM were retrieved from PubMed, Embase, Cochrane Library, and Web of Science up to February 29, 2024. The Cochrane quality scoring system was applied to assess study quality, and data were analyzed using R and Stata. The study was registered in PROSPERO (Registration No.: CRD42024501722).

Results: Thirty-seven RCTs involving 1,989 patients were included. Among the adjunctive therapies, scaling and root planing (SRP) with local satranidazole gel (SZ) achieved the best improvement in probing depth (PD) and clinical attachment level (CAL); SRP with systemic amoxicillin (AMX) significantly improved bleeding on probing (BOP); SRP with systemic doxycycline (Doxy) or antimicrobial photodynamic therapy (aPDT) was most effective for reducing glycated hemoglobin (HbA1c%); and SRP with diode laser (DL) improved fasting blood sugar (FBS) most effectively.

Conclusion: SRP combined with local SZ may improve PD and CAL in patients with periodontitis and T2DM. Systemic AMX may enhance BOP outcomes, while DOXY or aPDT may help reduce HbA1c. DL may contribute to better FBS improvement.

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非手术牙周治疗对2型糖尿病合并牙周炎患者的疗效：一项系统综述和贝叶斯网络meta分析。

目的：本研究旨在通过网络meta分析评估牙周基础治疗联合各种辅助治疗对牙周炎合并2型糖尿病（T2DM）患者牙周炎症及血糖控制的影响。方法：检索截至2024年2月29日的PubMed、Embase、Cochrane Library和Web of Science中涉及牙周炎和T2DM患者的随机对照试验（RCTs）。采用Cochrane质量评分系统评价研究质量，使用R和Stata对数据进行分析。本研究已在普洛斯彼罗（PROSPERO）注册。: CRD42024501722)。结果：纳入37项随机对照试验，涉及1989例患者。在辅助治疗中，局部沙硝唑凝胶（SZ）刮治和刨根（SRP）对探探深度（PD）和临床附着水平（CAL）的改善效果最好；SRP联合全身阿莫西林（AMX）显著改善探查出血（BOP）；SRP联合多西环素（Doxy）或抗菌光动力治疗（aPDT）对降低糖化血红蛋白（HbA1c%）最有效；而SRP联合二极管激光（DL）对空腹血糖（FBS）的改善效果最好。结论：SRP联合局部SZ可改善牙周炎和T2DM患者的PD和CAL。系统性AMX可能提高BOP结果，而DOXY或aPDT可能有助于降低HbA1c。DL可能有助于更好地改善FBS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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