Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis.

IF 2.6 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

BMC Oral Health Pub Date : 2025-05-02 DOI:10.1186/s12903-025-05876-9

Mohammadreza Shafiei, Shayan Mardi, Soodeh Ghadimi, Helia Poorshahbazi, Roozbeh Pourabbas, Mohammadamin Keykhah, Hosein Rafiemanesh

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引用次数: 0

Abstract

Background: Oral complications following cancer treatment are a challenging issue for oncologists. Several studies have demonstrated the efficacy of biotics in the prevention and treatment of oral complications in thyroid and head and neck cancers.

Methods: Following the PRISMA criteria, a systematic review and meta-analysis of included studies on efficacy, safety, dosage, and duration of treatment was performed.

Results: A total of 12 randomized controlled trials and a total of 885 individuals were included in this meta-analysis. Our analysis showed that biotics had a slight but insignificant effect on the incidence of oral mucositis (Risk ratio (RR) = 0.90, 95% CI [0.79, 1.03]), and a significant impact on reducing the severity of oral mucositis (RR = 0.62, 95% CI [0.48, 0.80]). Biotics also had a slight but insignificant effect in developing xerostomia in thyroid and Head and neck cancer (HNC) patients. Subgroup meta-analysis demonstrated that Bifidobacterium-containing products were more effective than other blends.

Conclusion: Our findings demonstrated that biotics are effective and safe for HNC and thyroid patients suffering from oral complications.

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益生菌、益生元和共生菌对甲状腺和头颈癌患者口腔并发症的疗效和耐受性：一项系统综述和荟萃分析

背景：癌症治疗后的口腔并发症是肿瘤学家面临的一个具有挑战性的问题。一些研究已经证明了生物制剂在预防和治疗甲状腺癌和头颈癌的口腔并发症方面的功效。方法：遵循PRISMA标准，对纳入的疗效、安全性、剂量和治疗持续时间的研究进行系统评价和荟萃分析。结果：本meta分析共纳入12项随机对照试验，共纳入885名个体。我们的分析显示，生物制剂对口腔黏膜炎的发生率有轻微但不显著的影响（风险比(RR) = 0.90, 95% CI[0.79, 1.03]），对降低口腔黏膜炎的严重程度有显著影响（RR = 0.62, 95% CI[0.48, 0.80]）。在甲状腺癌和头颈癌（HNC）患者中，生物制剂对口干症的发生也有轻微但不显著的影响。亚组荟萃分析表明，含有双歧杆菌的产品比其他混合物更有效。结论：我们的研究结果表明，生物制剂对患有口腔并发症的HNC和甲状腺患者是有效和安全的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Oral Health DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

6.90%

发文量

481

审稿时长

6-12 weeks

期刊介绍： BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.