Exploring the anticancer potential of green synthesized Zn/Cu nanocomposites from olive leaves against lung cancer.

IF 2.5 3区 生物学
Jing Sun, Shu Mei Tang, Jing Sun, Wei Gao
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引用次数: 0

Abstract

Lung cancer remains one of the leading causes of cancer-related death worldwide, with a significant number of patients succumbing to the disease each year. Olea europaea, commonly known as the olive tree, offers a range of health benefits due to its rich content of antioxidants. In the present study, we have reported the green synthesis of a bimetallic nanocomposite of zinc and copper using the leaf extract of Olea europaea (Zn/Cu NCs@ Olea europaea). The nanoparticles were characterized using common chemical techniques. The antioxidant activity of Zn/Cu NCs@ Olea europaea was evaluated using the DPPH assay. The cytotoxicity and anti-lung cancer activity of Zn/Cu NCs@ Olea europaea were investigated using the MTT assay. The results of XRD analysis and FE-SEM imaging showed a crystalline structure for Zn/Cu NCs@ Olea europaea with a semi-spherical morphology and an average size of 49.37 nm. Zn/Cu NCs@ Olea europaea scavenged the free radical DPPH with an IC50 of 363.42 ± 5.02 µg/mL. Furthermore, Zn/Cu NCs@ Olea europaea exhibited acceptable anti-lung cancer activity by preventing growth in the cell lines SK-MES-1, A-549, and LK-2 with IC50 of 154.00 ± 1.83, 228.83 ± 10.59, and 250.55 ± 8.04 µg/mL respectively. The NPs were inactive against the normal cell lines of HUVEC even at high concentrations. The results of the study indicate that Zn/Cu NCs@ Olea europaea, which is green synthesized with a sufficient nano size, can be considered a potent anti-lung cancer agent.

探索橄榄叶绿色合成锌/铜纳米复合材料对肺癌的抗癌潜力。
肺癌仍然是全球癌症相关死亡的主要原因之一,每年有大量患者死于这种疾病。欧罗巴油橄榄,通常被称为橄榄树,由于其丰富的抗氧化剂含量,提供一系列的健康益处。在本研究中,我们报道了利用油橄榄叶提取物绿色合成锌和铜双金属纳米复合材料(Zn/Cu nccs @ Olea europaea)。采用常用的化学技术对纳米颗粒进行了表征。采用DPPH法评价Zn/Cu NCs@油橄榄的抗氧化活性。采用MTT法研究了锌/铜nccs @油橄榄的细胞毒性和抗肺癌活性。XRD分析和FE-SEM成像结果表明,Zn/Cu NCs@ Olea europaea的晶体结构为半球形,平均尺寸为49.37 nm。Zn/Cu nccs @油橄榄对自由基DPPH的清除作用IC50为363.42±5.02µg/mL。此外,锌/Cu nccs @ Olea europaea通过抑制SK-MES-1、A-549和pk -2细胞株的生长,具有良好的抗肺癌活性,IC50分别为154.00±1.83、228.83±10.59和250.55±8.04µg/mL。NPs在高浓度下对正常HUVEC细胞株无活性。研究结果表明,绿色合成且纳米尺寸足够的锌/铜nccs @油橄榄可被认为是一种有效的抗肺癌药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hereditas
Hereditas Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.80
自引率
3.70%
发文量
0
期刊介绍: For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.
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