Non-Linear Relationship Between Fasting C-Peptide and Retinopathy in Patients with Type 2 Diabetes Mellitus - A Retrospective Study.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-04-07 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S501361

Jicai Ma, Cong Han, Yuanyuan Lv, Hanqing Cai

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引用次数: 0

Abstract

Background: Previous research has demonstrated that fasting C-peptide (FCP) serves as a protective element against diabetic retinopathy. But the protective effect of elevated FCP levels against diabetic retinopathy (DR) remains uncertain when these levels exceed specific thresholds. This research aimed to investigate the intrinsic link between FCP concentration and DR in individuals with T2DM.

Methods: A total of 1661 individuals diagnosed with type 2 diabetes participated in this observational analysis, where DR was assessed as the primary outcome and categorized according to FCP levels. Curve fitting analysis and two-part linear regression models were applied to assess the relationship between DR and FCP, and exploratory analysis was conducted to identify the threshold.

Results: Our study found a non-linear relationship between the two, as well as a threshold effect at an FCP of 4.11 ng/mL. Below the critical value, each 1 ng/mL increase in FCP levels was associated with a 24% lower risk of DR (OR: 0.74, 95% CI: 0.64-0.86). Above the cutoff, the relationship did not reach statistical significance (OR: 1.52, 95% CI: 0.87-2.66).

Conclusion: There was a nonlinear relationship between FCP level and DR risk, which was negatively correlated at first but stabilized at a lower level when FCP>4.11 ng/mL.

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2型糖尿病患者空腹c肽与视网膜病变的非线性关系——一项回顾性研究

背景：先前的研究表明，空腹c肽（FCP）可作为糖尿病视网膜病变的保护因子。但当FCP水平超过特定阈值时，FCP水平升高对糖尿病视网膜病变（DR）的保护作用仍不确定。本研究旨在探讨T2DM患者FCP浓度与DR之间的内在联系。方法：共有1661名诊断为2型糖尿病的个体参与了这项观察性分析，DR被评估为主要结局，并根据FCP水平进行分类。采用曲线拟合分析和两部分线性回归模型评估DR与FCP之间的关系，并进行探索性分析以确定阈值。结果：我们的研究发现两者之间存在非线性关系，并且在FCP为4.11 ng/mL时存在阈值效应。低于临界值，FCP水平每增加1 ng/mL， DR风险降低24% （OR: 0.74, 95% CI: 0.64-0.86）。在截止点以上，相关性没有达到统计学意义（OR: 1.52, 95% CI: 0.87-2.66）。结论：FCP水平与DR风险呈非线性关系，初始呈负相关，当FCP>4.11 ng/mL时稳定在较低水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.