Influence of glucagon-like peptide-1 receptor agonists on renal parameters: a meta-analysis of randomized controlled trials.

IF 3.3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

BMC Endocrine Disorders Pub Date : 2025-05-07 DOI:10.1186/s12902-025-01948-7

Wenjing Li, Xiaoyan Liang, Na Sun, Daqing Zhang

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引用次数: 0

Abstract

Aims: To verify the influence of glucagon-like peptide-1 receptor agonists (GLP-1 RA) on renal function parameters in type 2 diabetes based on well-known randomized controlled trials (RCTs).

Methods: PubMed, Cochrane, Web of Science, Embase, and grey literature were searched for RCTs published until December 24, 2024. The quality of the RCTs was assessed using the Cochrane risk-of-bias tool. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were calculated for continuous variables using meta-analysis. The primary outcomes were composite renal function parameters, including serum creatinine (Cr) levels, estimated glomerular filtration rate (eGFR), urinary albumin excretion (UAE), and urinary albumin-to-creatinine ratio (UACR).

Results: Pooled data from 24 studies revealed that GLP-1 RA positively influenced renal outcomes in the type 2 diabetes group to some extent compared with that in the control group. GLP- 1 RA decreased serum creatinine levels (WMD=-0.10, 95%CI -0.19 to -0.01, I² = 33%, P < 0.05), eGFR(WMD = 0.54, 95% CI 0.19 to 0.90, I² = 27%, P < 0.05), UAE (WMD=-11.92, 95% CI - 23.50 to - 0.33, I² = 0%, P < 0.05) and UACR (WMD: -1.01 mg/g, 95% CI:-1.68, -0.34, I² = 15%, P < 0.05) in the type 2 diabetes group.

Conclusion: GLP-1 RA treatment significantly elevated eGFR, decreased the UACR, and positively influenced renal function outcomes in the type 2 diabetes group.

Clinical trial number: Not applicable.

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胰高血糖素样肽-1受体激动剂对肾脏参数的影响：随机对照试验的荟萃分析

目的：通过知名的随机对照试验（RCTs）验证胰高血糖素样肽-1受体激动剂（GLP-1 RA）对2型糖尿病患者肾功能参数的影响。方法：检索PubMed、Cochrane、Web of Science、Embase和灰色文献，检索截止到2024年12月24日发表的rct。使用Cochrane风险偏倚工具评估随机对照试验的质量。使用meta分析计算连续变量的加权平均差（WMD）和95%置信区间（ci）。主要结局是综合肾功能参数，包括血清肌酐（Cr）水平、肾小球滤过率（eGFR）、尿白蛋白排泄（UAE）和尿白蛋白/肌酐比值（UACR）。结果：24项研究的汇总数据显示，与对照组相比，GLP-1 RA对2型糖尿病组的肾结局有一定程度的积极影响。GLP-1 RA降低血清肌酐水平（WMD=-0.10, 95%CI为-0.19 ~ -0.01,I2 = 33%, P 2 = 27%, P 2 = 0%, P 2 = 15%， P）结论：GLP-1 RA治疗可显著提高2型糖尿病组eGFR，降低UACR，对肾功能结局有积极影响。临床试验号：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-

CiteScore

4.40

自引率

0.00%

发文量

280

审稿时长

>12 weeks

期刊介绍： BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.