Biomarker-Based Models Utilizing the Albumin-Fibrinogen Ratio Effectively Predict Peritoneal Metastasis in Patients with Gastric Cancer: A Retrospective Study.

IF 2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Chun-Yang Shang, Xue-Pu Sun, Xue-Song Dong, Yang-Shuai Wang, Xiao Chen, Hai-Quan Qiao
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引用次数: 0

Abstract

Objective: Peritoneal carcinomatosis (PC) is a common pattern of recurrence in gastric cancer patients and is associated with a poor prognosis. This study aimed to evaluate the predictive value of the albumin-fibrinogen ratio (AFR) for PC in patients with gastric cancer and to develop two preoperative prediction models.

Methods: A total of 745 gastric cancer patients were included in this study. Preoperative AFR, along with other serum markers and clinical tumor characteristics, was assessed. Univariate and multivariate logistic regression analyses were performed to determine the odds ratios (ORs) and 95% confidence intervals (CIs) of the independent variables. Propensity score matching (PSM) was used to control for potential confounders, and one-way ANOVA was conducted to evaluate differences in distribution between groups. Two prediction models incorporating the independent predictive indicators were constructed and validated via receiver operating characteristic (ROC) curves.

Results: Poorly differentiated type (OR 2.679; P = 0.001), nondiffuse morphological type (OR 2.123; P = 0.040), BMI < 23.550 kg/m2 (OR 4.635; P = 0.001), AFR < 11.275 (OR 2.895; P = 0.003) and CA199 ≥ 73.615 U/mL (OR 2.040; P = 0.037) were identified as independent risk factors for PC in patients with gastric cancer. After PSM, the AFR remained the only inflammatory marker that was independently associated with PC (P = 0.003). AFR demonstrated consistent robustness in predicting PC across multiple sample sets. Among all the independent risk factors, the AFR had the highest area under the curve (AUC) for ROC analysis (AUC 0.648; 95% CI 0.580-0.715). Two combination models incorporating the AFR demonstrated enhanced predictive ability: Combination Model 1 (AUC 0.759; 95% CI 0.699-0.820) and Combination Model 2 (AUC 0.801; 95% CI 0.744-0.859).

Conclusions: The preoperative AFR serves as a useful indicator for predicting PC. Two reliable prediction models based on the AFR have been developed.

基于生物标志物的模型利用白蛋白-纤维蛋白原比率有效预测胃癌患者腹膜转移:一项回顾性研究。
目的:腹膜癌(PC)是胃癌患者常见的复发类型,且预后较差。本研究旨在评价白蛋白-纤维蛋白原比值(AFR)对胃癌患者PC的预测价值,并建立两种术前预测模型。方法:本研究共纳入745例胃癌患者。术前评估AFR,以及其他血清标志物和临床肿瘤特征。进行单因素和多因素logistic回归分析,确定自变量的比值比(ORs)和95%置信区间(CIs)。采用倾向评分匹配(PSM)控制潜在混杂因素,采用单因素方差分析评估组间分布差异。建立了两个独立预测指标的预测模型,并通过受试者工作特征(ROC)曲线进行验证。结果:低分化型(OR 2.679;P = 0.001),非弥漫性形态型(OR 2.123;P = 0.040), bmi 2(或4.635;结论:术前AFR可作为预测PC的有效指标。建立了两个可靠的基于AFR的预测模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Medical Science
Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
4.70
自引率
0.00%
发文量
126
期刊介绍: Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.
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