Reappraising the TNM staging system for oral cavity squamous cell carcinoma: an age-related prognosis analysis.

IF 2.2 3区医学 Q2 OTORHINOLARYNGOLOGY

European Archives of Oto-Rhino-Laryngology Pub Date : 2025-08-01 Epub Date: 2025-04-25 DOI:10.1007/s00405-025-09385-x

Amit Ritter, Eyal Yosefof, Nofar Edri, Noga Kurman, Gideon Bachar, Thomas Shpitzer, Aviram Mizrachi

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引用次数: 0

Abstract

Objective: Research on age and prognosis for oral cavity squamous cell carcinomas (OSCCs) has shown inconsistent results. We aimed to establish age as an independent prognostic factor and determine an age cutoff for staging in OSCC.

Methods: Electronic records were reviewed for all OSCC patients treated between 2000 and 2020.

Results: The study involved 250 patients, identifying a mortality cutoff age of 65 through Receiver Operating Characteristic curve analysis (sensitivity 77%, specificity 49%). Patients ≥ 65 had lower survival rates for early-stage (TNM I-II; 63.5% vs. 96%, p < 0.001) and advanced-stage (TNM III-IV; 37.5% vs. 62%, p = 0.011) diseases. A proposed age-based TNM staging system categorized ≥ 65 as Stage III/IV, with comparable survival rates confirmed in a revised analysis.

Conclusion: The study identifies age, with a 65-year cutoff, as an independent prognostic factor in OSCC and highlights its role in improving current staging systems.

Level of evidence: III.

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重新评估口腔鳞状细胞癌的TNM分期系统：年龄相关的预后分析。

目的：口腔鳞状细胞癌（OSCCs）的年龄与预后的研究结果不一致。我们的目的是建立年龄作为一个独立的预后因素，并确定年龄在OSCC分期的界限。方法：回顾2000年至2020年期间所有OSCC患者的电子记录。结果：该研究纳入了250例患者，通过受试者工作特征曲线分析确定了65岁的死亡截止年龄（敏感性77%，特异性49%）。≥65岁的患者早期(TNM I-II；结论：该研究确定年龄（65岁截止）是OSCC的独立预后因素，并强调其在改善当前分期系统中的作用。证据水平：III。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.