Knowledge Mapping and Global Research Trends of Ginseng Polysaccharides: a Bibliometric Analysis with Visualizations from 1985 to 2023.

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL

Drug Design, Development and Therapy Pub Date : 2025-04-09 eCollection Date: 2025-01-01 DOI:10.2147/DDDT.S508387

Pingli Mo, Bowen Gao, Rui Wang, Shiying Huang, Qiugu Chen, Muxia Li, Jiazhen Wu, Shangbin Zhang, Jianping Chen

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引用次数: 0

Abstract

Background: Panax ginseng C. A. Meyer (Ginseng) has a lengthy historical background of utilization and is frequently utilized for the treatment and prevention of various diseases. In recent times, researchers have shown an increasing inclination towards investigating the extraction, purification, structural analysis, and pharmacological properties of polysaccharides present in ginseng. However, there was still a lack of comprehensive and integrated analysis of ginseng polysaccharides.

Methods: This study employed the Web of Science Core Collection (WoSCC) as the data source and utilized software tools including Bibliometrix R Package, VOSviewer, and CiteSpace for the purpose of conducting data visualization and analysis of ginseng polysaccharides publications.

Results: China emerged as the foremost and most impactful nation in the realm of ginseng polysaccharide research, fostering robust collaborative ties with Republic of Korea and the USA. Yifa Zhou was the most influential author and the International Journal of Biological Macromolecules exerted as the significant influence in this field. The reference DUBOIS M, 1956, ANAL CHEM, V28, P350 received the highest citations. Through a comprehensive examination results of keywords clustering, keywords with the strong burst, and trend topic, the research hot directions of ginseng polysaccharides were focused on structural analysis and pharmacological activities. Specifically, gut microbiota and oxidative stress were active research hotspots of investigating the pharmacological activities of ginseng polysaccharides at present, it also was corroborated in disciplinary category analysis.

Conclusion: This study revealed the multidimensional field of research on ginseng polysaccharides. Current hot research directions encompassed structural analysis and pharmacological activities in this field, with research hotspots focused on exploring the pharmacological activities of ginseng polysaccharides in gut microbiota and oxidative stress.

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人参多糖的知识图谱和全球研究趋势：1985年至2023年的可视化文献计量分析。

背景：人参具有悠久的使用历史背景，经常用于治疗和预防各种疾病。近年来，研究人员越来越倾向于研究人参多糖的提取、纯化、结构分析和药理特性。然而，目前还缺乏对人参多糖的全面、综合的分析。方法：本研究以Web of Science Core Collection （WoSCC）为数据源，利用Bibliometrix R Package、VOSviewer、CiteSpace等软件工具对人参多糖文献进行数据可视化分析。结果：中国成为人参多糖研究领域最重要和最具影响力的国家，与韩国和美国建立了强有力的合作关系。其中，周一发是最具影响力的作者，《国际生物大分子杂志》在该领域具有重要影响。文献DUBOIS M， 1956, ANAL CHEM, V28， P350被引频次最高。通过关键词聚类、强爆发关键词和趋势话题的综合考察结果，将人参多糖的研究热点方向集中在结构分析和药理活性方面。其中，肠道菌群和氧化应激是目前研究人参多糖药理活性的活跃研究热点，在学科分类分析中也得到了印证。结论：本研究开辟了人参多糖研究的多维领域。目前该领域的热点研究方向包括结构分析和药理活性，研究热点集中在探索人参多糖在肠道微生物群和氧化应激中的药理活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.