Systemic inflammation as a mediator in the link between obesity and depression: Evidence from a nationwide cohort study.

IF 3.4 2区医学 Q2 PSYCHIATRY

BMC Psychiatry Pub Date : 2025-05-05 DOI:10.1186/s12888-025-06892-3

Xiaoqing Wang, Xinyue Liang, Ming Jiang, Ling Wei, Xiangpeng Shi, Fang Fang, Jing Cang

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引用次数: 0

Abstract

Background: Obesity and depression are major public health issues with a complex, bidirectional relationship potentially involving systemic inflammation.

Methods: Using a diverse sample from the National Health and Nutrition Examination Survey (NHANES) (n = 11,324; weighted population = 456,457,366), we examined the associations between obesity, systemic inflammation, and depression. Obesity was classified by Body Mass Index (BMI), depressive symptoms were assessed with the Patient Health Questionnaire-9 (PHQ-9), and systemic inflammation was measured using markers like Neutrophil-to-Lymphocyte Ratio (NLR), Systemic Inflammation Response Index (SIRI), and Systemic Immune-Inflammation Index (SII). Weighted logistic regression models were used to assess relationships between obesity, inflammation, and depression. Linear regression evaluated BMI's association with inflammation markers, and Restricted Cubic Spline (RCS) analysis explored their interrelationships. Subgroup analyses and interaction tests were conducted, and mediation analysis examined the role of inflammation markers in mediating the obesity-depression association.

Results: Class III obesity was associated with higher inflammatory marker levels and increased depression risk. Mediation analysis showed NLR, SIRI, and SII mediated 5.2%, 5.9%, and 6.1% of the obesity-depression relationship.

Conclusions: Systemic inflammation partially mediates the relationship between obesity and depression.

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全身性炎症在肥胖和抑郁之间起中介作用：来自全国队列研究的证据。

背景：肥胖和抑郁是主要的公共卫生问题，具有复杂的双向关系，可能涉及全身性炎症。方法：使用来自国家健康和营养检查调查（NHANES）的不同样本(n = 11,324；加权人群= 456,457,366)，我们研究了肥胖、全身性炎症和抑郁之间的关系。通过体重指数（BMI）对肥胖进行分类，使用患者健康问卷-9 （PHQ-9）评估抑郁症状，使用中性粒细胞与淋巴细胞比率（NLR）、全身炎症反应指数（SIRI）和全身免疫炎症指数（SII）等标志物测量全身性炎症。采用加权逻辑回归模型评估肥胖、炎症和抑郁之间的关系。线性回归评估BMI与炎症标志物的关系，限制三次样条（RCS）分析探讨它们之间的相互关系。通过亚组分析和相互作用检验，并通过中介分析检验炎症标志物在肥胖-抑郁关联中的中介作用。结果：III级肥胖与较高的炎症标志物水平和抑郁风险增加有关。中介分析显示NLR、SIRI和SII介导了5.2%、5.9%和6.1%的肥胖-抑郁关系。结论：全身性炎症在肥胖和抑郁之间起部分介导作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Psychiatry 医学-精神病学

CiteScore

5.90

自引率

4.50%

发文量

716

审稿时长

3-6 weeks

期刊介绍： BMC Psychiatry is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of psychiatric disorders, as well as related molecular genetics, pathophysiology, and epidemiology.