Olfactory projection neuron rewiring in the brain of an ecological specialist.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-04-25 DOI:10.1016/j.celrep.2025.115615

Benedikt R Dürr, Enrico Bertolini, Suguru Takagi, Justine Pascual, Liliane Abuin, Giovanna Lucarelli, Richard Benton, Thomas O Auer

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引用次数: 0

Abstract

Animal behaviors can differ greatly between closely related species. These behavioral changes are frequently linked to sensory system modifications, but central brain cell-type alterations might also be involved. Here, we develop advanced genetic tools to compare homologous central neurons in Drosophila sechellia, an ecological specialist, with the generalist Drosophila melanogaster. Through systematic morphological analysis of olfactory projection neurons (PNs), we reveal that the global anatomy of these second-order neurons is conserved. However, high-resolution, quantitative comparisons identify a striking case of convergent rewiring of PNs in two olfactory pathways critical for D. sechellia's host location. Calcium imaging and labeling of pre-synaptic sites in these evolved D. sechellia PNs indicate that species-specific connections with third-order partners are formed. This work demonstrates that peripheral sensory evolution is accompanied by selective wiring changes in the central brain to facilitate ecological specialization and paves the way to compare other cell types throughout the nervous system.

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一位生态专家大脑中的嗅觉投射神经元重新布线。

关系密切的物种之间的动物行为差异很大。这些行为变化通常与感觉系统的改变有关，但中枢脑细胞类型的改变也可能涉及其中。在这里，我们开发了先进的遗传工具来比较同源中枢神经元的果蝇sechellia，一个生态专家，与多面手果蝇melanogaster。通过对嗅觉投射神经元（PNs）的系统形态学分析，揭示了这些二级神经元的整体解剖结构是保守的。然而，高分辨率的定量比较发现了一个惊人的情况，即PNs在两个嗅觉通路中收敛性重新布线，这对瓢虫的宿主位置至关重要。钙成像和标记在这些进化的水蛭PNs突触前位点表明，与第三级伙伴形成了物种特异性连接。这项工作表明，外周感觉进化伴随着中枢大脑的选择性连线变化，以促进生态专门化，并为比较整个神经系统中的其他细胞类型铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.