Coacervation-responsive cubosome containing hyaluronic acid and albumin complex.

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2025-04-15 DOI:10.1177/08853282251334466

Hyeon Ki Son, Panalee Pomseethong, Jin-Chul Kim

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引用次数: 0

Abstract

Coacervation-responsive cubosomes were prepared by loading a complex of hydrophobically modified hyaluronic acid (HmHA) and hydrophobically modified albumin (HmAlb) and steviol glycoside (SG) into the water channels. Hyaluronic acid and albumin were modified with a lipid chain, and the HmHA and HmAlb were characterized by ¹H NMR and FT-IR spectroscopy, respectively. The formation of the HmHA/HmAlb coacervate complex was optimized when the mass ratio was 1:9 under pH 4.0 conditions. The phase transition temperature of the cubic phase complex was observed to increase slightly from 60.9°C to 61.6°C as a result of the inclusion of the coacervate complex, as evidenced by differential scanning calorimetry. The maximum release degree of SG at 22°C was suppressed to 30.9% due to the coacervate at pH 3, and it was promoted to 75.9% at pH 5.5 due to the dissolution of the electrostatic complex as the pH value increased. The monoolein of the cubosDome enhanced the in vitro skin permeation of the cubosomal SG, as it could play a role as a skin permeation enhancer. The coacervation-responsive cubosome could be potentially used as a drug carrier that can release its content in a pH-controlled manner.

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含有透明质酸和白蛋白复合物的凝聚反应性立方体。

通过将疏水修饰透明质酸（HmHA）、疏水修饰白蛋白（HmAlb）和甜菊糖苷（SG）的复合物加载到水通道中，制备了具有凝聚反应的立方体体。用脂链修饰透明质酸和白蛋白，用1H NMR和FT-IR分别对其进行表征。在pH 4.0条件下，质量比为1:9时，hha /HmAlb凝聚络合物的形成效果最佳。差示扫描量热法表明，由于凝聚配合物的加入，立方相配合物的相变温度从60.9℃略微升高到61.6℃。在22℃时，SG的最大释放度因pH值为3时的凝聚而被抑制为30.9%；在pH值为5.5时，随着pH值的增加，静电配合物的溶解使SG的最大释放度提高到75.9%。立方体体的单油素增强了立方体体SG的体外皮肤透性，可能起到皮肤透性促进剂的作用。这种具有凝聚反应的立方体体可以作为一种药物载体，以ph控制的方式释放其内容物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.