Prognostic impact of surgery on thymic malignancies with concurrent or previous extrathymic malignancies: a retrospective analysis from 1998 to 2021.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiothoracic Surgery Pub Date : 2025-04-16 DOI:10.1186/s13019-025-03442-6

Guo-Sheng Li, Gui-Yu Feng, Jun Liu, Zhan-Yu Xu, Jian-Ji Guo, Tao Huang, Hua-Fu Zhou, Guan-Biao Liang, Nuo Yang

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引用次数: 0

Abstract

Objective: There is limited research on the impact of surgery on the cancer-specific survival (CSS) of patients with malignant thymoma and concurrent or previous extrathymic malignancies (PMTEMs). This retrospective analysis evaluated the prognostic value of surgery in PMTEMs.

Methods: Data were sourced from the SEER database, encompassing PMTEMs aged 20-90 with confirmed diagnoses and comprehensive clinical information. Patients were categorized into surgical (n = 105) and nonsurgical (n = 25) groups. Propensity score matching (PSM) was employed to mitigate selection bias, resulting in well-balanced baseline characteristics between the groups. Kaplan-Meier curves and the log-rank test were used to investigate the prognostic value of surgery in PMTEMs.

Results: Using PSM, the matching of characteristics between the surgical and nonsurgical groups was well-balanced, ensuring the reliability of subsequent analyses. Pre-PSM, the CSS in the surgical group was significantly better than that in the nonsurgical group (p <.001). Similarly, according to the post-PSM data, the CSS for PMTEMs in the surgical group remained superior to that in the nonsurgical group, which indicates that the survival advantage of the surgical group persisted after PSM (p =.030). Additionally, PMTEMs with smaller thymomas (≤ 5 cm) had a significant advantage in CSS compared to those with larger thymomas (p = .046).

Conclusions: In conclusion, this study shows that surgery may significantly improve the survival rate of PMTEMs.

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胸腺恶性肿瘤并发或既往胸腺外恶性肿瘤手术对预后的影响：1998年至2021年的回顾性分析

目的：关于手术对恶性胸腺瘤合并胸腺外恶性肿瘤（PMTEMs）患者癌症特异性生存（CSS）影响的研究有限。本回顾性分析评估了手术治疗pmtem的预后价值。方法：数据来源于SEER数据库，包括20-90岁确诊的PMTEMs和全面的临床信息。患者分为手术组（n = 105）和非手术组（n = 25）。倾向得分匹配（PSM）被用来减轻选择偏差，导致组之间的基线特征平衡良好。采用Kaplan-Meier曲线和log-rank检验探讨手术对pmtem的预后价值。结果：使用PSM，手术组和非手术组之间的特征匹配良好，保证了后续分析的可靠性。psm前，手术组的CSS明显优于非手术组(p)。结论：本研究表明，手术可显著提高PMTEMs的生存率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiothoracic Surgery 医学-心血管系统

CiteScore

2.50

自引率

6.20%

发文量

286

审稿时长

4-8 weeks

期刊介绍： Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.