Sulfonated and sulfated lignans/neolignans from an aqueous extract of Isatis indigotica roots

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-10 DOI:10.1080/10286020.2025.2483810

Jia-Yi Feng , Yu-Feng Liu , Xiao-Qiang Lei , Qing-Lan Guo , Jian-Gong Shi

引用次数: 0

Abstract

Five sulfonated and sulfated lignans/neolignans (1–5), together with a neolignan analogue (6), were isolated from an aqueous extract of the Isatis indigotica roots (ban lan gen). Their structures were determined by spectral data analysis in combination with electronic circular dichroism (ECD) and NMR calculations. Among the isolates, 1 and 2 are sulfonated 7,9′-epoxylignans, while 3–5 are either sulfated or sulfonated 4′,7-epoxy-8,3′-neolignans. In the preliminary bioassay, 2 and 3 exhibited moderate inhibitory activities against TGF-β induced HSC-T6 cell activation.

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从板蓝根的水提取物中提取的磺化和磺化木脂素/新木脂素。

从板蓝根（ban lan gen）的水提取物中分离出五种磺化和磺化木脂素/新木脂素（1-5），以及一种新木脂素类似物(6)。通过光谱数据分析，结合电子圆二色性（ECD）和核磁共振计算确定了它们的结构。其中，1和2为磺化的7,9′-环氧木聚糖，3 -5为磺化或磺化的4′，7-环氧-8,3′-新木聚糖。在初步的生物实验中，2和3对TGF-β诱导的HSC-T6细胞活化表现出适度的抑制活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.