Functional connectivity across multi-frequency bands in patients with tension-type headache: a resting-state fMRI retrospective study.

IF 2.9 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

BMC Medical Imaging Pub Date : 2025-05-01 DOI:10.1186/s12880-025-01599-z

Jili Wang, Hongjie Shen, Qinyan Xu, Shuxian Zhang, Tian Li, Yun Zheng

{"title":"Functional connectivity across multi-frequency bands in patients with tension-type headache: a resting-state fMRI retrospective study.","authors":"Jili Wang, Hongjie Shen, Qinyan Xu, Shuxian Zhang, Tian Li, Yun Zheng","doi":"10.1186/s12880-025-01599-z","DOIUrl":null,"url":null,"abstract":"Objectives: Tension-type headache (TTH) is the most common nervous system disorder worldwide. This study aimed to examine abnormal network-level brain functional connectivity (FC) alterations in patients with TTH across multi-frequency bands.Methods: The study enrolled 63 subjects, comprising 32 patients with TTH and 31 healthy controls (HC). According to our team's previous research, the brain regions with abnormal ReHo in the conventional frequency band (0.01-0.08 Hz) and the slow-5 band (0.01-0.027 Hz) were chosen as seed regions of interest (ROIs). Subsequently, the FC between ROIs and the entire brain analysis across various frequency bands was calculated to evaluate network-level alterations, and differences between the TTH and HC were analyzed. Pearson's correlation analysis was conducted to assess the relationship between significantly altered FC values in two frequency bands and visual analog score (VAS) in TTH patients.Results: In the slow-5 band (0.01-0.027 Hz), FC between right medial superior frontal gyrus and right medial temporal pole/right inferior temporal gyrus as well as right middle frontal gyrus and left supramarginal gyrus of TTH patients exhibited significantly higher, compared to the HC group, while FC between right middle frontal gyrus and right lateral occipital cortex reduced. For the correlation results, there was no correlation between abnormal brain regions of FC and VAS score.Conclusions: Changes in FC within brain regions associated with TTH are linked to pain processing. And the altered FC in TTH patients were frequency dependent. These initial observations could enhance our understanding of TTH's pathophysiological mechanism and offer insights for its future diagnosis and treatment.","PeriodicalId":9020,"journal":{"name":"BMC Medical Imaging","volume":"25 1","pages":"145"},"PeriodicalIF":2.9000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046950/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Medical Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12880-025-01599-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: Tension-type headache (TTH) is the most common nervous system disorder worldwide. This study aimed to examine abnormal network-level brain functional connectivity (FC) alterations in patients with TTH across multi-frequency bands.

Methods: The study enrolled 63 subjects, comprising 32 patients with TTH and 31 healthy controls (HC). According to our team's previous research, the brain regions with abnormal ReHo in the conventional frequency band (0.01-0.08 Hz) and the slow-5 band (0.01-0.027 Hz) were chosen as seed regions of interest (ROIs). Subsequently, the FC between ROIs and the entire brain analysis across various frequency bands was calculated to evaluate network-level alterations, and differences between the TTH and HC were analyzed. Pearson's correlation analysis was conducted to assess the relationship between significantly altered FC values in two frequency bands and visual analog score (VAS) in TTH patients.

Results: In the slow-5 band (0.01-0.027 Hz), FC between right medial superior frontal gyrus and right medial temporal pole/right inferior temporal gyrus as well as right middle frontal gyrus and left supramarginal gyrus of TTH patients exhibited significantly higher, compared to the HC group, while FC between right middle frontal gyrus and right lateral occipital cortex reduced. For the correlation results, there was no correlation between abnormal brain regions of FC and VAS score.

Conclusions: Changes in FC within brain regions associated with TTH are linked to pain processing. And the altered FC in TTH patients were frequency dependent. These initial observations could enhance our understanding of TTH's pathophysiological mechanism and offer insights for its future diagnosis and treatment.

查看原文本刊更多论文

紧张性头痛患者多频段功能连接：静息状态功能磁共振成像回顾性研究

目的：紧张性头痛（TTH）是世界上最常见的神经系统疾病。本研究旨在研究TTH患者在多频段的异常网络级脑功能连接（FC）改变。方法：本研究共纳入63例受试者，包括32例TTH患者和31例健康对照（HC）。根据课题组前期研究，选取常规频带（0.01 ~ 0.08 Hz）和慢5频带（0.01 ~ 0.027 Hz）的ReHo异常脑区作为兴趣种子区（roi）。随后，计算各频段roi和全脑分析之间的FC，以评估网络水平的变化，并分析TTH和HC之间的差异。采用Pearson相关分析评估TTH患者两个频带FC值显著改变与视觉模拟评分（VAS）之间的关系。结果：在慢-5波段（0.01 ~ 0.027 Hz）， TTH患者右侧额上内侧回与右侧颞内极/右侧颞下回、右侧额中回与左侧边缘上回之间的FC显著高于HC组，右侧额中回与右侧枕外侧皮层之间的FC显著降低。相关结果显示，FC异常脑区与VAS评分无相关性。结论：与TTH相关的大脑区域内FC的变化与疼痛处理有关。TTH患者FC改变呈频率依赖性。这些初步的观察结果可以增强我们对TTH病理生理机制的理解，并为其未来的诊断和治疗提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.60

自引率

3.70%

发文量

198

审稿时长

27 weeks

期刊介绍： BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.