Prevalence of peripheral arterial disease and its association with claudication in individuals with type 2 Diabetes Mellitus: a prospective cross-sectional study in Brazil.

IF 0.8 Q4 PERIPHERAL VASCULAR DISEASE

Jornal Vascular Brasileiro Pub Date : 2025-04-18 eCollection Date: 2025-01-01 DOI:10.1590/1677-5449.202400852

Gislaine Bonete da Cruz, Cibele Teresinha Dias Ribeiro, Camila Maciel de Oliveira, Rosangela Roginski Rea, Fernando Augusto Lavezzo Dias

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引用次数: 0

Abstract

Background: Few studies have described the prevalence of peripheral arterial disease (PAD) in the diabetic population of Brazil.

Objectives: To evaluate the prevalence of PAD and its association with the presence of claudication and to compare risk factors for atherosclerosis between subjects with and without PAD.

Methods: An analytical, observational, prospective, cross-sectional study was conducted with 150 volunteers with type 2 Diabetes Mellitus (T2DM) treated at a university endocrinology outpatient clinic (Federal University of Paraná, Curitiba, Brazil) and assessed using the ankle-brachial index (ABI) and the Edinburgh Claudication Questionnaire.

Results: ABI was evaluated in 143 volunteers (7 did not meet the inclusion criteria). Six individuals had an ABI > 1.4. Excluding these cases and adopting an ABI ≤ 0.9 to identify PAD, the prevalence of PAD was 14.6% (20 of 137), 15.8% in men (6 of 38), and 14.1% in women (14 of 99). We identified twenty-five participants with borderline ABI (18.2%). Claudication was present in 25% of subjects with PAD; however, only 15% had typical claudication. A significant association with the presence of typical claudication was observed only when ABI values were stratified above or below 1.0 (p = 0.04, Fisher's exact test). Participants with PAD were older (median difference: 5.5 years, 95% CI 3.0 to 9.0, p < 0.001) and tended to have a longer duration of DM and higher BMI.

Conclusions: The prevalence of PAD in T2DM volunteers with no prior screening was 14.6% and 75% were asymptomatic.

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外周动脉疾病的患病率及其与2型糖尿病患者跛行的关系：巴西的一项前瞻性横断面研究

背景：很少有研究描述了外周动脉疾病（PAD）在巴西糖尿病人群中的患病率。目的：评估PAD的患病率及其与跛行存在的关系，并比较有和没有PAD的受试者之间动脉粥样硬化的危险因素。方法：对150名在巴西库里蒂巴帕拉帕拉联邦大学内分泌门诊治疗的2型糖尿病（T2DM）患者进行了一项分析性、观察性、前瞻性、横断面研究，并使用踝肱指数（ABI）和爱丁堡跛行问卷进行了评估。结果：143名志愿者进行了ABI评估（7名不符合纳入标准）。6人的ABI指数为bb0.1。排除这些病例并采用ABI≤0.9诊断PAD， PAD患病率为14.6%(20 / 137)，男性患病率为15.8%(6 / 38)，女性患病率为14.1%（14 / 99）。我们确定了25名边缘性ABI患者（18.2%）。25%的PAD患者存在跛行；然而，只有15%的人有典型的跛行。只有当ABI值高于或低于1.0时，才观察到与典型跛行存在显著关联（p = 0.04， Fisher精确检验）。PAD患者年龄较大（中位差异：5.5岁，95% CI 3.0 ~ 9.0, p < 0.001），糖尿病持续时间更长，BMI更高。结论：在没有事先筛查的T2DM志愿者中，PAD的患病率为14.6%，75%无症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal Vascular Brasileiro Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Vascular Brasileiro is editated and published quaterly to select and disseminate high-quality scientific contents concerning original research, novel surgical and diagnostic techniques, and clinical observations in the field of vascular surgery, angiology, and endovascular surgery. Its abbreviated title is J. Vasc. Bras., which should be used in bibliographies, footnotes and bibliographical references and strips.