Predictive Value of Body Composition Indicators in Early Pregnancy for Gestational Diabetes Mellitus.

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Annals of Nutrition and Metabolism Pub Date : 2025-04-26 DOI:10.1159/000546025

Yun Hong, Mengfei Ren, Jiajia Li, Jingran Jiao, Jiaqiang Cheng, Qingli Bo

{"title":"Predictive Value of Body Composition Indicators in Early Pregnancy for Gestational Diabetes Mellitus.","authors":"Yun Hong, Mengfei Ren, Jiajia Li, Jingran Jiao, Jiaqiang Cheng, Qingli Bo","doi":"10.1159/000546025","DOIUrl":null,"url":null,"abstract":"Introduction: Gestational diabetes mellitus (GDM) is a common complication of pregnancy. It is characterized by normal or possibly impaired glucose metabolism before pregnancy and abnormal glucose metabolism during pregnancy. We evaluate the predictive value of body composition indicators in early pregnancy for GDM.Methods: Pregnant women who visited Huaibei Maternal and Child Health Hospital from November 2022 to April 2023 were selected as study participants. Body composition indicators were measured using bioelectrical impedance assessment at 11-14 weeks of gestation. Study subjects completed a 75-g oral glucose tolerance test (OGTT) at 24-28 weeks of gestation. Relationships between body composition indicators and GDM were explored using multivariate logistic regression. Additionally, the predictive value of body composition indicators for GDM was assessed through the receiver operating characteristic (ROC) curve and restricted cubic spline (RCS).Results: Five hundred eighty-eight participants were enrolled, 100 of whom had a diagnosis of GDM (17.9%). We found that percent body fat (PBF) and visceral fat index (VFI) were associated with a higher risk of GDM, with adjusting ORs of 1.82 (95% CI = 1.50-2.21) and 6.10 (95% CI = 3.91-9.51) after adjusting for confounders, respectively. The ROC showed that PBF and VFI were highly predictive values for GDM. The RCS displayed that there was a J-shaped connection between 3-point OGTT plasma glucose and PBF. There was a nonlinear relationship between 1-h plasma glucose and VFI.Conclusions: The findings suggest that PBF and VFI have high predictive value for GDM.","PeriodicalId":8269,"journal":{"name":"Annals of Nutrition and Metabolism","volume":" ","pages":"1-11"},"PeriodicalIF":3.2000,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nutrition and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546025","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Gestational diabetes mellitus (GDM) is a common complication of pregnancy. It is characterized by normal or possibly impaired glucose metabolism before pregnancy and abnormal glucose metabolism during pregnancy. We evaluate the predictive value of body composition indicators in early pregnancy for GDM.

Methods: Pregnant women who visited Huaibei Maternal and Child Health Hospital from November 2022 to April 2023 were selected as study participants. Body composition indicators were measured using bioelectrical impedance assessment at 11-14 weeks of gestation. Study subjects completed a 75-g oral glucose tolerance test (OGTT) at 24-28 weeks of gestation. Relationships between body composition indicators and GDM were explored using multivariate logistic regression. Additionally, the predictive value of body composition indicators for GDM was assessed through the receiver operating characteristic (ROC) curve and restricted cubic spline (RCS).

Results: Five hundred eighty-eight participants were enrolled, 100 of whom had a diagnosis of GDM (17.9%). We found that percent body fat (PBF) and visceral fat index (VFI) were associated with a higher risk of GDM, with adjusting ORs of 1.82 (95% CI = 1.50-2.21) and 6.10 (95% CI = 3.91-9.51) after adjusting for confounders, respectively. The ROC showed that PBF and VFI were highly predictive values for GDM. The RCS displayed that there was a J-shaped connection between 3-point OGTT plasma glucose and PBF. There was a nonlinear relationship between 1-h plasma glucose and VFI.

Conclusions: The findings suggest that PBF and VFI have high predictive value for GDM.

查看原文本刊更多论文

妊娠早期体成分指标对妊娠期糖尿病的预测价值。

妊娠期糖尿病（GDM）是妊娠期常见的并发症。其特点是妊娠前糖代谢正常或可能受损，妊娠期糖代谢异常。我们评估妊娠早期身体成分指标对GDM的预测价值。方法：选取2022年11月至2023年4月在淮北市妇幼保健院就诊的孕妇作为研究对象。在妊娠11-14周采用生物电阻抗评估（BIA）测定体成分指标。研究对象在妊娠24-28周完成75g口服葡萄糖耐量试验（OGTT）。采用多变量logistic回归方法探讨体成分指标与GDM的关系。此外，通过受试者工作特征曲线（ROC）和受限三次样条（RCS）评估体成分指标对GDM的预测价值。结果：588名参与者入组，其中100人诊断为GDM（17.9%）。我们发现体脂百分比（PBF）和内脏脂肪指数（VFI）与较高的GDM风险相关，调整混杂因素后的or分别为1.82 （95%CI = 1.50~2.21）和6.10 （95%CI = 3.91~9.51）。ROC显示PBF和VFI是GDM的高度预测值。RCS显示，3点OGTT血糖与PBF呈j型关系。1小时血糖与VFI呈非线性关系。结论：PBF和VFI对GDM有较高的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of Nutrition and Metabolism 医学-内分泌学与代谢

CiteScore

6.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.