Can microglia negatively impact myelin development in autism?

IF 2.9 2区医学 Q2 NEUROSCIENCES

Cerebral cortex Pub Date : 2025-04-01 DOI:10.1093/cercor/bhaf100

Gustavo Della-Flora Nunes

引用次数: 0

Abstract

There is emerging evidence for the involvement of microglia and oligodendrocytes in the pathophysiology of autism. The accompanying review article summarize this evidence and explore potential ways microglia can modulate oligodendrocyte function in autism. Further investigation of the role of microglia and oligodendrocytes in autism may help clarify autism pathogenesis and holds promise to ameliorate autism phenotypes.

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小胶质细胞会对自闭症患者的髓磷脂发育产生负面影响吗？

有新的证据表明，小胶质细胞和少突胶质细胞参与自闭症的病理生理。随后的综述文章总结了这一证据，并探讨了小胶质细胞调节自闭症少突胶质细胞功能的潜在途径。进一步研究小胶质细胞和少突胶质细胞在自闭症中的作用可能有助于阐明自闭症的发病机制，并有望改善自闭症的表型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebral cortex 医学-神经科学

CiteScore

6.30

自引率

8.10%

发文量

510

审稿时长

2 months

期刊介绍： Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.