Application of Two-Dimensional Shear Wave Elastography in Evaluating Liver Reserve Function in Patients With Liver Cancer.

IF 1.2 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2025-04-25 DOI:10.1002/jcu.24015

Bijuan Hu, Zhiping Huang, Liyin Huang

{"title":"Application of Two-Dimensional Shear Wave Elastography in Evaluating Liver Reserve Function in Patients With Liver Cancer.","authors":"Bijuan Hu, Zhiping Huang, Liyin Huang","doi":"10.1002/jcu.24015","DOIUrl":null,"url":null,"abstract":"Background: Shear wave elastography (SWE) is an emerging noninvasive imaging technique for assessing liver fibrosis. This meta-analysis aimed to evaluate the diagnostic accuracy of SWE compared to conventional imaging techniques.Methods: A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science databases. Nine studies were included, and diagnostic performance metrics, including sensitivity, specificity, diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC), were pooled using meta-analysis. Publication bias was assessed using Deeks' funnel plot asymmetry test.Results: The pooled sensitivity and specificity of SWE were 0.88 (95% CI: 0.83-0.92) and 0.88 (95% CI: 0.83-0.91), respectively. The positive likelihood ratio (PLR) was 7.07 (95% CI: 5.26-9.50), and the negative likelihood ratio (NLR) was 0.14 (95% CI: 0.09-0.20). The DOR was 51.85 (95% CI: 29.80-90.19), and the area under the SROC curve (AUC) was 0.94 (95% CI: 0.91-0.96), indicating excellent diagnostic accuracy. Fagan nomogram analysis further confirmed SWE's clinical utility by significantly improving post-test probability. No significant publication bias was detected (p = 0.26).Conclusion: SWE is a highly accurate and reliable tool for diagnosing liver fibrosis, demonstrating superior diagnostic performance compared to conventional imaging techniques. SWE has significant potential to serve as a noninvasive alternative to liver biopsy in the clinical assessment of liver fibrosis.","PeriodicalId":15386,"journal":{"name":"Journal of Clinical Ultrasound","volume":" ","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Ultrasound","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jcu.24015","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ACOUSTICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Shear wave elastography (SWE) is an emerging noninvasive imaging technique for assessing liver fibrosis. This meta-analysis aimed to evaluate the diagnostic accuracy of SWE compared to conventional imaging techniques.

Methods: A systematic search was conducted in PubMed, Embase, Cochrane Library, and Web of Science databases. Nine studies were included, and diagnostic performance metrics, including sensitivity, specificity, diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC), were pooled using meta-analysis. Publication bias was assessed using Deeks' funnel plot asymmetry test.

Results: The pooled sensitivity and specificity of SWE were 0.88 (95% CI: 0.83-0.92) and 0.88 (95% CI: 0.83-0.91), respectively. The positive likelihood ratio (PLR) was 7.07 (95% CI: 5.26-9.50), and the negative likelihood ratio (NLR) was 0.14 (95% CI: 0.09-0.20). The DOR was 51.85 (95% CI: 29.80-90.19), and the area under the SROC curve (AUC) was 0.94 (95% CI: 0.91-0.96), indicating excellent diagnostic accuracy. Fagan nomogram analysis further confirmed SWE's clinical utility by significantly improving post-test probability. No significant publication bias was detected (p = 0.26).

Conclusion: SWE is a highly accurate and reliable tool for diagnosing liver fibrosis, demonstrating superior diagnostic performance compared to conventional imaging techniques. SWE has significant potential to serve as a noninvasive alternative to liver biopsy in the clinical assessment of liver fibrosis.

查看原文本刊更多论文

二维横波弹性成像在评价肝癌患者肝脏储备功能中的应用。

背景：横波弹性成像（SWE）是一种新兴的评估肝纤维化的无创成像技术。本荟萃分析旨在评估与传统成像技术相比，SWE的诊断准确性。方法：系统检索PubMed、Embase、Cochrane Library和Web of Science数据库。纳入了9项研究，并使用荟萃分析汇总了诊断性能指标，包括敏感性、特异性、诊断优势比（DOR）和受试者工作特征曲线下面积（AUC）。采用Deeks漏斗图不对称检验评价发表偏倚。结果：SWE的敏感性和特异性分别为0.88 （95% CI: 0.83-0.92）和0.88 （95% CI: 0.83-0.91）。阳性似然比（PLR）为7.07 (95% CI: 5.26 ~ 9.50)，阴性似然比（NLR）为0.14 （95% CI: 0.09 ~ 0.20）。DOR为51.85 (95% CI: 29.80 ~ 90.19)， SROC曲线下面积（AUC）为0.94 (95% CI: 0.91 ~ 0.96)，诊断准确率较高。Fagan nomogram分析进一步证实了SWE显著提高后验概率的临床应用价值。未发现显著发表偏倚（p = 0.26）。结论：SWE是一种高度准确和可靠的诊断肝纤维化的工具，与传统成像技术相比，具有优越的诊断性能。在肝纤维化的临床评估中，SWE具有作为肝活检的非侵入性替代方法的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.