Persistent homology-based optical properties of microscopic turbid media for realistic light propagation analysis.

IF 2.9 2区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
Biomedical optics express Pub Date : 2025-03-26 eCollection Date: 2025-04-01 DOI:10.1364/BOE.557290
Jirawit Jiracheewee, Yu Shimojo, Takahiro Nishimura
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引用次数: 0

Abstract

The optical properties of microscopic turbid media are critical for understanding light-tissue interactions with applications in biomedical imaging and diagnostics. However, traditional scattering coefficient-based methods are limited in their ability to capture topological heterogeneities within tissue structures, which play a crucial role in describing the relationship between microscopic tissue characteristics and their corresponding light propagation behaviors. In this study, we propose using persistent homology-based persistent images (PIs) as a descriptor and optical property of microscopic tissues. As a proof of concept, we analyzed particle-distributed turbid media with uniform and clustered particle distributions by persistent homology analysis, demonstrating that PIs can capture topological characteristics that are not discernible using traditional scattering coefficient-based methods. Light propagation simulations using the beam propagation method (BPM) demonstrated that PIs correlate with optical behaviors, such as beam centroid displacement and distortion, providing a foundation for linking microscopic topological heterogeneities to light propagation behaviors. Our results validate PIs as a meaningful and predictive optical property, bridging microscopic turbid media topology with their light propagation behaviors. This work establishes PIs as a potential optical property of microscopic tissue, capturing its topological characteristics and offering predictive insights into light propagation behaviors.

显微混浊介质持久同源光学性质的真实光传播分析。
微观混浊介质的光学特性对于理解光组织相互作用在生物医学成像和诊断中的应用至关重要。然而,传统的基于散射系数的方法在捕获组织结构内拓扑异质性的能力方面受到限制,而拓扑异质性在描述微观组织特征与其相应的光传播行为之间的关系方面起着至关重要的作用。在这项研究中,我们提出使用基于持久同源的持久图像(pi)作为显微组织的描述符和光学性质。作为概念证明,我们通过持续同源性分析分析了均匀和聚集颗粒分布的颗粒分布浑浊介质,证明pi可以捕获传统基于散射系数的方法无法识别的拓扑特征。利用光束传播方法(BPM)进行的光传播模拟表明,pi与光束质心位移和畸变等光学行为相关,为将微观拓扑异质性与光传播行为联系起来提供了基础。我们的研究结果验证了pi是一种有意义和可预测的光学特性,将微观浑浊介质拓扑与其光传播行为联系起来。这项工作确立了pi作为微观组织的潜在光学特性,捕捉其拓扑特征并为光传播行为提供预测性见解。
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来源期刊
Biomedical optics express
Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS
CiteScore
6.80
自引率
11.80%
发文量
633
审稿时长
1 months
期刊介绍: The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.
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