Cross-sectional associations of proteomic age acceleration with self-reported physical and mental health and depression symptoms among those with and without cancer.
Matia Solomon, R Bhatia, S Wang, A H Blaes, E A Platz, W Guan, P I Jewett, A Prizment
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引用次数: 0
Abstract
Purpose: Accelerated aging may affect quality of life (QOL), and having cancer may further complicate that relationship. We assessed the cross-sectional association of a novel proteomic aging clock (PAC) with self-reported physical and mental health and depression symptoms among individuals with and without cancer.
Methods: Data for this cross-sectional analysis came from the prospective Atherosclerosis Risk in Communities (ARIC) Study. We estimated proteomic age acceleration (PAA), i.e., the deviation of PAC from chronological age, at two ARIC visits (1990-1992 and 2011-2013). We used linear regression models to estimate the association of PAA and change in PAA with self-reported physical (PCS) and mental health (MCS) as well as depression symptoms, separately for cancer survivors and individuals without cancer.
Results: Among cancer survivors, mean PCS, MCS, and depression scores were 44.0, 54.8, and 6.7, respectively; and 46.6, 55.3, and 6.5 among those without a cancer history. PAA was associated with lower PCS (adjusted coefficients per additional 5 years; cancer survivors, - 1.73, 95% CI - 3.11, - 0.35; without a cancer history, - 2.70, 95% CI - 3.90, - 1.51) and with higher depression scores among those without a cancer history (0.57, 95% CI 0.27, 0.88). Neither PAA nor change in PAA was associated with MCS in either population.
Conclusion: We found some evidence for a cross-sectional association of PAA with self-reported physical health, but little evidence for an association with mental health and depression scores.
Implications for cancer survivors: PAA may have stronger implications for physical than for mental health outcomes among those with and without cancer.
期刊介绍：
Cancer survivorship is a worldwide concern. The aim of this multidisciplinary journal is to provide a global forum for new knowledge related to cancer survivorship. The journal publishes peer-reviewed papers relevant to improving the understanding, prevention, and management of the multiple areas related to cancer survivorship that can affect quality of care, access to care, longevity, and quality of life. It is a forum for research on humans (both laboratory and clinical), clinical studies, systematic and meta-analytic literature reviews, policy studies, and in rare situations case studies as long as they provide a new observation that should be followed up on to improve outcomes related to cancer survivors. Published articles represent a broad range of fields including oncology, primary care, physical medicine and rehabilitation, many other medical and nursing specialties, nursing, health services research, physical and occupational therapy, public health, behavioral medicine, psychology, social work, evidence-based policy, health economics, biobehavioral mechanisms, and qualitative analyses. The journal focuses exclusively on adult cancer survivors, young adult cancer survivors, and childhood cancer survivors who are young adults. Submissions must target those diagnosed with and treated for cancer.
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